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Two-dimensional and three-dimensional cardiac magnetic resonance feature-tracking myocardial strain analysis in acute myocarditis patients with preserved ejection fraction

  • Marco Gatti
  • Anna Palmisano
  • Riccardo FalettiEmail author
  • Giulia Benedetti
  • Laura Bergamasco
  • Fabio Bioletto
  • Giovanni Peretto
  • Simone Sala
  • Francesco De Cobelli
  • Paolo Fonio
  • Antonio Esposito
Original Paper

Abstract

To explore the potential role of two- (2D) and three-dimensional (3D) cardiac magnetic resonance (CMR) feature tracking (FT) myocardial strain analysis in identifying sub-clinical myocardial systolic and diastolic dysfunction in acute myocarditis patients with preserved ejection fraction (EF). Prospective two centre study-control study. Thirty patients (9 female, 37.2 ± 11.8 years.) with a CMR diagnosis of acute myocarditis according to the Lake Louise Criteria and preserved EF (≥ 55%) were included in the analysis. CMR data from 24 healthy volunteers (11 female, 36.2 ± 12.5 years.) served as control. 2D and 3D LV tissue tracking analysis were performed in a random fashion by two double-blinded operators. Variables were checked for normality and analysed with parametric test. The baseline characteristics of myocarditis patients with preserved EF and the healthy volunteers were perfectly comparable, except for the LV mass index and T1 and T2 mapping values (p < 0.001). The results of the interobserver variability in the 2D and 3D LV CMR FT myocardial strain analysis were p > 0.42, ICC > 0.80 and η2 > 0.98. There was no statistical difference in 2D and 3D global radial, circumferential and longitudinal strain peak (%) and both systolic and diastolic strain rate (1/s) between acute myocarditis with preserved EF and healthy volunteers (all p = ns). There were no difference in 2D and 3D global radial, circumferential and longitudinal strain peak and both systolic and diastolic strain rate of the LV between acute myocarditis patients with preserved ejection fraction and healthy volunteers.

Keywords

Cardiovascular magnetic resonance Acute myocarditis Feature tracking Myocardial strain analysis Diastolic dysfunction 

Notes

Acknowledgements

This research was partially supported by a grant from the Italian Ministry of Health: “Giovani Ricercatori—Ricerca Finalizzata”, project number GR-2013-02356832. The funder had no role in this study.

Compliance with ethical standards

Conflict of interest

All the authors are aware of the content of the manuscript and have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • Marco Gatti
    • 1
  • Anna Palmisano
    • 2
    • 3
  • Riccardo Faletti
    • 1
    Email author
  • Giulia Benedetti
    • 2
    • 3
  • Laura Bergamasco
    • 1
  • Fabio Bioletto
    • 1
  • Giovanni Peretto
    • 3
    • 4
  • Simone Sala
    • 4
  • Francesco De Cobelli
    • 2
    • 3
  • Paolo Fonio
    • 1
  • Antonio Esposito
    • 2
    • 3
  1. 1.Department of Surgical Sciences, Radiology UnitUniversity of TurinTurinItaly
  2. 2.Clinical and Experimental Radiology Unit, Experimental Imaging CenterSan Raffaele Scientific InstituteMilanItaly
  3. 3.Vita Salute San Raffaele UniversityMilanItaly
  4. 4.Department of Cardiac Electrophysiology and ArrhythmologySan Raffaele Scientific InstituteMilanItaly

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