The prognostic value of ultra low-dose thallium myocardial perfusion protocol using CZT SPECT
- 20 Downloads
The purpose of this study was to assess the prognostic value of ultra-low dose thallium myocardial perfusion imaging. Three hundred and sixty-six patients (245 men) underwent ultra-low dose stress-redistribution imaging on CZT SPECT camera GE Discovery NM 530c. The stress test was performed by bicycle ergometry or regadenoson injection. The activity of 0.5 MBq (0.014 mCi) Tl-201 chloride per kilogram of body weight was administered. The stress images were acquired immediately and redistribution images were taken after 3 h. Patient follow-up was focused on combined end-point (death, myocardial infarction, unstable angina, revascularization and hospitalization for heart failure). Data analysis was performed from hospital database, with a mean period 23 months. Patients with revascularization within 1 month after SPECT was excluded as revascularization for diagnosis. Ischaemia on SPECT was found in 72 patients, 294 patients were without ischaemia. In patients with ischaemia there were 21 (29.2%) subjects with cardiac events, and 23 (7.9%) in patients without ischaemia (HR 4.15, 95% CI 2.30–7.51, p < 0.0001). Ultra-low dose thallium perfusion imaging using CZT camera provides very good prognostic results in assessment of myocardial ischaemia.
KeywordsMyocardial perfusion Thallium Low-dose CZT SPECT Prognostic value
This study was supported by the project no. LQ1605 from the National Program of Sustainability II (MEYS CR).
Compliance with ethical standards
Conflict of interest
All authors declare none conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
- 9.Barone-Rochette G, Zoreka F, Djaileb L, Piliero N, Calizzano A et al (2018) Diagnostic value of stres thallium-201/rest technetium-99m-sestamibi sequential dual isotope high-speed myocadial perfusion imaging for the dectection of haemodynamically significant coronary artery stenosis. J Nucl Cardiol. https://doi.org/10.1007/s12350-018-1189-8 Google Scholar
- 14.Hachamovitch R, Berman DS, Shaw LJ et al (1998) Incremental prognostic value of myocardial perfusion single photon emission computed tomography for the prediction of cardiac death: differential stratification for risk of cardiac death and myocardial infarction. Circulation 97:535–543CrossRefGoogle Scholar