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Left ventricular myocardial T1 mapping and strain analysis evaluate cardiac abnormality in hypothyroidism

  • Min Liu
  • Weifang Liu
  • Peiyao Zhang
  • Jing An
  • Guang Wang
Original Paper
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Abstract

Cardiovascular Magnetic Resonance (CMR)-based T1 mapping and Heart Deformation Analysis (CMR-HDA) can assess the myocardial tissue characteristic and strain of cardiomyopathy. Whether they can assess cardiac abnormality of hypothyroidism (HT) is unknown. We aim to analysis left ventricular (LV) T1 values and strain of patients with overt HT (OHT) and subclinical HT (SHT) with CMR-based T1 mapping and HDA. This study prospectively included 32 OHT patients, 23 SHT patients and 27 healthy controls who underwent CMR. LV T1 mapping was obtained with a Modified Look-Locker Inversion Recovery sequence while LV circumferential strain (LVCS) and radial strain (LVRS), LV longitudinal strain (LVLS) were respectively analyzed on the short-axial and four-chamber cines with HDA. LV Eject Fraction among three groups were similar (p = 0.676). LV myocardial T1 correlated with LVCS (r = 0.734, p < 0.001) and LVRS (r = − 0.340, p = 0.011). LV myocardial T1 of OHT patients significantly increased in comparison with SHT patients (t = 5.403, p < 0.001) and normal controls (t = 10.197, p < 0.001), meanwhile, LV myocardial T1 of SHT patients were higher than that of controls (t = 2.629, p = 0.013). Compared with SHT patients (t = 1.925, p = 0.031) and normal controls (t = 2.875, p = 0.006), LVCS of OHT patients reduced while LVCS of SHT patients were lower than that of normal controls (t = 2.451, p = 0.020). LVRS of SHT patients were higher than OHT patients (t = 2.778, p = 0.008), but comparable to normal controls (t = 1.134, p = 0.266). LVLS of SHT and OHT significantly impaired in comparison with normal control. The increased LV myocardial T1 value and reduced strain were found in HT. CMR-based LV myocardial T1 and stain analysis are useful to evaluate myocardial tissue characteristic and mechanics in both overt and subclinical hypothyroidism.

Keywords

Hypothyroidism Cardiovascular magnetic resonance imaging T1 mapping Heart deformation analysis Strain 

Abbreviations

CMR

Cardiovascular magnetic resonance

HDA

Heart deformation analysis

HT

Hypothyroidism

OHT

Overt hypothyroidism

SHT

Subclinical hypothyroidism

LVCS

Left ventricular circumferential strain

LVRS

Left ventricular radial strain

LVLS

Left ventricular longitudinal strain

LVSS

Left ventricular shear strain

LVEF

LV eject fraction

TSH

Thyroid-stimulating hormone

FT4

Free thyroxine

FT3

Free triiodothyronine

Tg-Ab

Antithyroglobulin

TPO-Ab

Antithyroid peroxidase antibody

TE

Echo time

TR

Repetition time

MOLLI

Modified look-locker inversion recovery

SSFP

Steady state free precession

ESV

End diastolic volume

EDV

End systolic volume

SV

Stroke volume

ECV

Extracellular volume fraction

Notes

Acknowledgements

This research is supported by Beijing Natural Science Foundation (7182149) and National Natural Science Foundation of China (81871328).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  • Min Liu
    • 1
  • Weifang Liu
    • 1
  • Peiyao Zhang
    • 1
  • Jing An
    • 2
  • Guang Wang
    • 3
  1. 1.Department of RadiologyChina-Japan Friendship HospitalBeijingChina
  2. 2.Collaborations NE AsiaSiemens HealthcareBeijingChina
  3. 3.Department of EndocrinologyBeijing Chaoyang Hospital of Capital Medical UniversityBeijingChina

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