Changes in left ventricular function in patients with aortic regurgitation 12 months after transapical transcatheter aortic valve implantation

  • Ming-dan Deng
  • Xin Wei
  • Xiao-ling Zhang
  • Xiao-dong Li
  • Gu-yue Liu
  • Da Zhu
  • Ying-qiang Guo
  • Hong TangEmail author
Original Paper


Transcatheter aortic valve implantation (TAVI) is an established treatment for high surgical risk aortic stenosis patients; in recent years, it has also been used in patients with pure/dominant aortic regurgitation (AR). This study aimed to determine the impact of transapical TAVI on left ventricle myocardial mechanics in AR patients. Thirty AR patients (70% men; mean age, 72.8 ± 4.3 years) were enrolled. Conventional echocardiography was performed on all patients before and 12 months after TAVI. Three-dimensional speckle tracking was accomplished in 20 AR patients for the evaluation of global longitudinal strain, global circumferential strain, twist, torsion, apical rotation and basal rotation. Preoperative left ventricular ejection fraction (LVEF), global longitudinal strain (GLS), global circumferential strain (GCS), twist, torsion and apical rotation were impaired in AR patients compared with controls. Mean left ventricular (LV) end-diastolic diameter (from 62.9 ± 7.3 to 52.0 ± 6.8 mm, p < 0.001), LV end-diastolic volume (from 199.4 ± 55.0 to 130.1 ± 48.9 mL, p < 0.001), and LV mass index (179.8 ± 52.2–134.4 ± 42.5 g/m2, p = 0.001) decreased 12 months after TAVI. Interestingly, GLS (from − 17.2 ± 3.2 to − 18.9 ± 3.7, p = 0.007) and GCS (from − 23.9 ± 4.9 to − 25.7 ± 5.0, p = 0.008) improved significantly, but LVEF did not significantly improve. In terms of the rotational mechanics, twist, rotation and basal rotation remained almost unchanged, whereas apical rotation (from 7.4 ± 4.0 to 5.5 ± 3.9, p = 0.009) was significantly impaired after transapical TAVI. Our results indicate that LV function was improved in terms of myocardial deformation but worsened in terms of apical rotation 12 months after TAVI in AR patients. Three-dimensional speckle tracking echocardiography appears to be a sensitive method for detecting subtle cardiac remodeling after TAVI.


Aortic regurgitation Transcatheter aortic valve implantation Three-dimensional speckle tracking Strain 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study protocol was approved by the hospital ethics committee.

Informed consent

Written informed consent was obtained from all participants.


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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  • Ming-dan Deng
    • 1
  • Xin Wei
    • 1
  • Xiao-ling Zhang
    • 1
  • Xiao-dong Li
    • 1
  • Gu-yue Liu
    • 1
  • Da Zhu
    • 2
  • Ying-qiang Guo
    • 2
  • Hong Tang
    • 1
    Email author
  1. 1.Department of Cardiology, West China HospitalSichuan UniversityChengduPeople’s Republic of China
  2. 2.Department of Cardiovascular Surgery, West China HospitalSichuan UniversityChengduPeople’s Republic of China

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