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The International Journal of Cardiovascular Imaging

, Volume 34, Issue 9, pp 1339–1347 | Cite as

Paclitaxel-coated balloon treatment for functionally nonsignificant residual coronary lesions after balloon angioplasty

  • Ae-Young Her
  • Eun-Seok ShinEmail author
  • Joo Myung Lee
  • Scot Garg
  • Joon-Hyung Doh
  • Chang-Wook Nam
  • Bon-Kwon Koo
Original Paper

Abstract

There is limited data on the efficacy of paclitaxel-coated balloon (PCB) compared to stents for de novo coronary lesions. The purpose of this study was to compare the efficacy of PCB treatment with stent implantation for de novo coronary lesions after successful plain old balloon angioplasty (POBA) guided by fractional flow reserve (FFR). In 200 patients scheduled for elective percutaneous coronary intervention (PCI) for de novo lesions, FFR was measured after POBA (POBA–FFR). If POBA–FFR was ≥ 0.75, patients were treated with PCB (PCB group, n = 78) or stent (Stent group, n = 73). If POBA–FFR was < 0.75, stent was implanted as planned (Reference group, n = 42). The primary endpoint was late lumen loss at 9 months and the secondary endpoint was adverse cardiac events (cardiac death, myocardial infarction, target lesion thrombosis, or repeat revascularization) at 12 months follow-up. There was no between-group differences in the POBA–FFR (0.87 ± 0.05 in PCB, 0.89 ± 0.06 in stent, p = 0.101). At 9 months, late lumen loss was significantly lower in the PCB group compared to the Stent group (0.05 ± 0.33 vs. 0.59 ± 0.76 mm, p < 0.001). Adverse cardiac events were not different between the PCB, Stent and Reference groups (2.6, 5.5, and 9.5% respectively; p = 0.430 for PCB vs. Stent group; p = 0.229 for the reference vs. both other groups). PCB treatment guided by POBA–FFR showed excellent 9 months angiographic and functional results, as well as comparable 12 months clinical outcomes, compared with stent implantation for de novo coronary lesions.

Keywords

Paclitaxel-coated balloon Stent Fractional flow reserve Balloon angioplasty De novo lesion Coronary artery disease 

Notes

Acknowledgements

The authors wish to thank Eok Rae Cho and Jeong Hoon Jang for their strenuous efforts and unsurpassed assistance in preparing the manuscript. Data analysis was performed by Hyun Ho Kim, Division of Biostatistics, University of Ulsan College of Medicine.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interest.

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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Ae-Young Her
    • 1
  • Eun-Seok Shin
    • 2
    Email author
  • Joo Myung Lee
    • 3
  • Scot Garg
    • 4
  • Joon-Hyung Doh
    • 5
  • Chang-Wook Nam
    • 6
  • Bon-Kwon Koo
    • 7
  1. 1.Division of Cardiology, Department of Internal MedicineKangwon National University School of MedicineChuncheonSouth Korea
  2. 2.Division of Cardiology, Ulsan University HospitalUniversity of Ulsan College of MedicineUlsanSouth Korea
  3. 3.Department of Internal Medicine and Cardiovascular Center, Samsung Medical CenterSungkyunkwan University School of MedicineSeoulSouth Korea
  4. 4.East Lancashire Hospitals NHS TrustBlackburnUK
  5. 5.Division of CardiologyInje University Ilsan Paik HospitalGoyangSouth Korea
  6. 6.Department of Internal Medicine, Dongsan Medical CenterKeimyung University College of MedicineTaeguSouth Korea
  7. 7.Department of Internal Medicine and Cardiovascular CenterSeoul National University HospitalSeoulSouth Korea

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