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Quantitative assessment of myocardial strain with displacement encoding with stimulated echoes MRI in patients with coronary artery disease

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Abstract

To determine the diagnostic performance and reproducibility of strain assessment with displacement encoding with stimulated echoes (DENSE) cardiovascular magnetic resonance (CMR) in identifying contractile abnormalities in myocardial segments with late gadolinium enhancement (LGE). DENSE CMR was obtained on short-axis planes of the left ventricle (LV) in 24 patients with suspected coronary artery disease. e1 and e2 strains of LV wall were quantified. Cine MRI was acquired to determine percent systolic wall thickening (%SWT), followed by (LGE) CMR. The diagnostic performance of e1, e2 and %SWT for predicting the presence of LGE was evaluated by receiver operating characteristics (ROC) analysis. Myocardial scar on LGE CMR was observed in 91 (24 %) of 384 segments. The area under ROC curve for predicting the segments with LGE was 0.874 by e1, 0.916 by e2 and 0.828 by %SWT (p = 0.001 between e2 and %SWT). Excellent inter-observer reproducibility was found for strain [Intraclass correlation coefficient (ICC) = 0.962 for e1, 0.955 for e2] as compared with %SWT (ICC = 0.790). DENSE CMR can be performed as a part of routine CMR study and allows for quantification of myocardial strain with high inter-observer reproducibility. Myocardial strain, especially e2 is useful in detecting altered abnormal systolic contraction in the segments with myocardial scar.

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Acknowledgments

This work was supported by JSPS KAKENHI Grant Number 23591762.

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Authors and Affiliations

  1. Department of Radiology, Mie University Hospital, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan

    Hideki Miyagi, Motonori Nagata, Kakuya Kitagawa, Shingo Kato, Shinichi Takase, Masaki Ishida & Hajime Sakuma

  2. Department of Clinical Physiology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden

    Andreas Sigfridsson

  3. Department of Cardiology, Mie University Hospital, Tsu, Mie, Japan

    Kaoru Dohi & Masaaki Ito

Authors
  1. Hideki Miyagi
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  2. Motonori Nagata
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  3. Kakuya Kitagawa
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  5. Shinichi Takase
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  6. Andreas Sigfridsson
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  9. Masaaki Ito
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  10. Hajime Sakuma
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Correspondence to Hajime Sakuma.

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Miyagi, H., Nagata, M., Kitagawa, K. et al. Quantitative assessment of myocardial strain with displacement encoding with stimulated echoes MRI in patients with coronary artery disease. Int J Cardiovasc Imaging 29, 1779–1786 (2013). https://doi.org/10.1007/s10554-013-0274-y

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  • DOI: https://doi.org/10.1007/s10554-013-0274-y

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