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Pre-diagnostic carbohydrate intake and treatment failure after radical prostatectomy for early-stage prostate cancer

  • Kyeezu Kim
  • Angela Kong
  • Robert C. Flanigan
  • Marcus L. Quek
  • Courtney M. P. Hollowell
  • Patricia P. Vidal
  • Jefferey Branch
  • Leslie A. Dean
  • Virgilia Macias
  • Andre A. Kajadacsy-Balla
  • Marian L. Fitzgibbon
  • Daisy Cintron
  • Li Liu
  • Vincent L. FreemanEmail author
Original Paper
  • 12 Downloads

Abstract

Purpose

An association between dietary carbohydrate intake and prostate cancer (PCa) prognosis is biologically plausible, but data are scarce. This prospective cohort study examined the relation between pre-diagnostic carbohydrate intake and treatment failure following radical prostatectomy for clinically early-stage PCa.

Methods

We identified 205 men awaiting radical prostatectomy and assessed their usual dietary intake of carbohydrates using the 110-item Block food frequency questionnaire. We also evaluated carbohydrate intake quality using a score based on the consumption of sugars relative to fiber, fat, and protein. Logistic regression analyzed their associations with the odds of treatment failure, defined as a detectable and rising serum prostate-specific antigen (PSA) or receiving androgen deprivation therapy (ADT) within 2 years.

Results

Sucrose consumption was associated with a higher odds and fiber consumption with a lower odds of ADT after accounting for age, race/ethnicity, body mass index, and tumor characteristics (odds ratio [OR] (95% confidence interval [CI]) 5.68 (1.71, 18.9) for 3rd vs. 1st sucrose tertile and 0.88 (0.81, 0.96) per gram of fiber/day, respectively). Increasing carbohydrate intake quality also associated with a lower odds of ADT (OR (95% CI) 0.78 (0.66, 0.92) per unit increase in score, range 0–12).

Conclusions

Pre-diagnostic dietary carbohydrate intake composition and quality influence the risk of primary treatment failure for early-stage PCa. Future studies incorporating molecular aspects of carbohydrate metabolism could clarify possible underlying mechanisms.

Keywords

Prostate cancer prognosis Treatment failure Dietary carbohydrate Insulin sensitivity 

Notes

Funding

Funding for this study was provided by NIH/NCI (Grant No. 5R01CA129140).

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Kyeezu Kim
    • 1
  • Angela Kong
    • 2
  • Robert C. Flanigan
    • 3
  • Marcus L. Quek
    • 3
  • Courtney M. P. Hollowell
    • 4
  • Patricia P. Vidal
    • 4
  • Jefferey Branch
    • 5
  • Leslie A. Dean
    • 6
  • Virgilia Macias
    • 7
  • Andre A. Kajadacsy-Balla
    • 7
  • Marian L. Fitzgibbon
    • 8
  • Daisy Cintron
    • 8
  • Li Liu
    • 1
  • Vincent L. Freeman
    • 1
    • 9
    Email author
  1. 1.Division of Epidemiology and Biostatistics, School of Public HealthUniversity of Illinois at Chicago School of Public HealthChicagoUSA
  2. 2.Department of Kinesiology and Nutrition, College of Applied Health SciencesUniversity of Illinois at ChicagoChicagoUSA
  3. 3.Department of Urology, Stritch School of MedicineLoyola University Medical CenterMaywoodUSA
  4. 4.Division of UrologyStroger, Cook County Health and Hospitals SystemChicagoUSA
  5. 5.Urology ServiceEdward Hines, Jr. VA HospitalHinesUSA
  6. 6.Department of UrologyUniversity of Miami Miller School of MedicineMiamiUSA
  7. 7.Department of PathologyUniversity of Illinois Hospital and Health Sciences SystemChicagoUSA
  8. 8.Institute for Health Research and PolicyUniversity of Illinois at Chicago School of Public HealthChicagoUSA
  9. 9.Institute for Health Research and PolicyUniversity of Illinois at Chicago School of Public HealthChicagoUSA

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