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Treatment patterns and survival differ between early-onset and late-onset colorectal cancer patients: the patient outcomes to advance learning network

  • Andrea N. Burnett-HartmanEmail author
  • J. David Powers
  • Jessica Chubak
  • Douglas A. Corley
  • Nirupa R. Ghai
  • Carmit K. McMullen
  • Pamala A. Pawloski
  • Andrew T. Sterrett
  • Heather Spencer Feigelson
Original Paper
  • 16 Downloads

Abstract

Purpose

Our objective was to describe differences in treatment patterns and survival between early-onset (< 50 years old) and late-onset colorectal cancer (CRC) patients in community-based health systems.

Methods

We used tumor registry and electronic health record data to identify and characterize patients diagnosed with adenocarcinoma of the colon or rectum from 2010 to 2014 at six US health systems in the patient outcomes to advance learning (PORTAL) network. We used logistic regression to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) comparing the distribution of tumor characteristics and treatment patterns in early-onset versus late-onset CRC. Cox regression models were used to estimate adjusted hazard ratios (HRs) and CIs comparing survival between early- and late-onset CRC patients.

Results

There were 1,424 early-onset and 10,810 late-onset CRC cases in our analyses. Compared to late-onset CRC, early-onset CRC was significantly associated with advanced-stage disease, high-grade histology, signet ring histology, and rectal or left colon location. After adjusting for differences in tumor and patient characteristics, early-onset patients were more likely than late-onset patients to have > 12 lymph nodes examined (OR 1.60, CI 1.37–1.87), to receive systemic therapy (chemotherapy or immunotherapy) within 6 months of diagnosis (OR 2.84, CI 2.40–3.37), and to have a reduced risk of CRC-specific death (HR 0.66, CI 0.56–0.79).

Conclusions

Early-onset CRC is associated with aggressive tumor characteristics, distal location, and systemic therapy use. Despite some adverse risk factors, these patients tend to have better survival than older onset patients.

Keywords

Colorectal cancer Early-onset Chemotherapy Treatment Survival 

Notes

Acknowledgments

This study used the infrastructure developed by the PORTAL (Patient Outcomes Research to Advance Learning) Network, a consortium of three integrated delivery systems (Kaiser Permanente, HealthPartners, and Denver Health) and their affiliated research centers. Research reported in this publication was funded through a Patient-Centered Outcomes Research Institute (PCORI) Award (CDRN-1306-04681 Phase II). The statements in this publication are solely the responsibility of the authors and do not necessarily represent the views of PCORI, its Board of Governors or Methodology Committee.

Compliance with ethical standards

Conflicts of interest

The authors declare no potential conflicts of interest.

Ethical approval

This study was conducted in accordance with the ethical standards of the institutional review board at Kaiser Permanente Colorado and with the 1964 Helsinki declaration and its later amendments.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Andrea N. Burnett-Hartman
    • 1
    • 7
    Email author
  • J. David Powers
    • 1
  • Jessica Chubak
    • 2
  • Douglas A. Corley
    • 3
  • Nirupa R. Ghai
    • 4
  • Carmit K. McMullen
    • 5
  • Pamala A. Pawloski
    • 6
  • Andrew T. Sterrett
    • 1
  • Heather Spencer Feigelson
    • 1
  1. 1.Institute for Health ResearchKaiser Permanente ColoradoDenverUSA
  2. 2.Kaiser Permanente Washington Health Research InstituteSeattleUSA
  3. 3.Division of ResearchKaiser Permanente Northern CaliforniaOaklandUSA
  4. 4.Department of Surgical Quality and OutcomesKaiser Permanente Southern CaliforniaPasadenaUSA
  5. 5.Center for Health ResearchKaiser Permanente NorthwestPortlandUSA
  6. 6.HealthPartners InstituteBloomingtonUSA
  7. 7.Institute for Health ResearchKaiser Permanente ColoradoAuroraUSA

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