Race and overall survival in men diagnosed with prostate cancer in the Department of Defense Military Health System, 1990–2010
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In the U.S. general population, black men experience poorer survival after prostate cancer (CaP) diagnosis compared to white men, and findings may be impacted by unequal access to healthcare. The objective of the study is to investigate racial differences in overall survival (OS) among Department of Defense beneficiaries diagnosed with CaP.
A retrospective cohort study was conducted utilizing the Automated Central Tumor Registry within the Military Healthcare System, a system designed to provide equal access. Men diagnosed with primary prostate adenocarcinomas between 1990 and 2010 [n = 18,484; 24% Non-Hispanic black (NHB), 76% Non-Hispanic white (NHW)] were followed through 2013 for vital status. Unadjusted Kaplan–Meier estimation curves and multivariable Cox proportional hazards (PH) regression models were used to examine racial differences in OS.
Age-specific Kaplan–Meier analyses showed equivalent OS for NHW and NHB men in all age groups, except for 75+, where NHB had poorer OS (p = 0.0048). Multivariable Cox PH models revealed no significant differences in OS for race (HR 1.02; 95% CI 0.95–1.08), except in men aged ≥ 75 years, where NHB men had poorer OS (HR 1.27; 95% CI 1.08–1.49).
Findings suggest that in a healthcare system designed for equal access, disparities in OS among men diagnosed with CaP may not exist.
KeywordsProstate cancer Survival Racial disparities Equal access
This project was supported by John P. Murtha Cancer Center, Walter Reed National Military Medical Center via the Uniformed Services University of the Health Sciences under the auspices of the Henry M. Jackson Foundation for the Advancement of Military Medicine. The authors thank the Joint Pathology Center (formerly Armed Forces Institute of Pathology) for providing the data. The authors would like to thank Ms. Elizabeth Butts for her input about the ACTUR and its compliance with the Commission on Cancer.
The content of this publication is the sole responsibility of the authors and does not necessarily reflect the views or policies of the Uniformed Services University of the Health Sciences (USUHS), the Department of Defense (DoD), or the Departments of the Army, Navy, or Air Force.
- 2.DeSantis C, Naishadham D, Jemal A (2013) Cancer statistics for African Americans. CA Cancer J Clin 63(3):151–166Google Scholar
- 4.Robbins HA et al (2015) Age at cancer diagnosis for blacks compared with whites in the United States. J Natl Cancer Inst. 107(3)Google Scholar
- 18.Defense Health Agency (2018) https://www.health.mil.About-MHS. Accessed 1 Oct 2018]
- 23.Commission on Cancer, Facility Oncology Registry Data Standards (2015) American College of SurgeonsGoogle Scholar
- 24.Commission on Cancer, Cancer Program Standards 2012: Ensuring Patient-Centered Care, in Data Quality (2012) American College of SurgeonsGoogle Scholar
- 25.Fritz A et al. (2000) International classification of diseases for oncology. World Health Organization, GenevaGoogle Scholar
- 27.American Joint Committee on Cancer (2002) AJCC cancer staging manual, 6th edn. Springer, New YorkGoogle Scholar
- 33.Arias E (2014) United States life tables, 2009, in national vital statistics reports. National Center for Health Statistics, Hyattsville, MD, p 63Google Scholar