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Cancer Causes & Control

, Volume 30, Issue 5, pp 465–475 | Cite as

Second primary lung cancer in United States Cancer Survivors, 1992–2008

  • Nicholas M. DoninEmail author
  • Lorna Kwan
  • Andrew T. Lenis
  • Alexandra Drakaki
  • Karim Chamie
Original paper
  • 53 Downloads

Abstract

Purpose

Lung cancer is common and lethal, and can occur in survivors of previous cancers. We sought to describe the incidence and mortality attributable to second primary lung cancers (SPLC) among survivors of other cancers, and to identify survivors at highest risk.

Methods

We identified adults diagnosed with a localized malignancy from non-pulmonary cancer sites from surveillance, epidemiology, and end results (SEER) data from 1992 to 2008. We explored factors associated with the incidence and death from SPLC using bivariable and multivariable models. Finally, we compared standardized incidence rates for SPLC in our cohort with the control arm of the National Lung Screening Trial (NLST), a randomized lung cancer screening trial.

Results

We identified 1,450,837 survivors of non-pulmonary cancers, of whom 25,472 developed SPLC at a mean (SD) follow-up of 5.7 (3.6) years. Over half (57%) of patients with SPLC died of the disease. Survivors of cancer of the hypopharynx, oropharynx, tonsil, and larynx, experienced SPLC at standardized incidence rates which greatly exceeded that observed in the control arm of the NLST (572/100,000 person-years). Additionally, survivors of bladder and esophageal cancer had rates that approached the NLST control arm rate. Increasing age and being divorced/widowed/separated were independent risk factors for SPLC in most primary cancer types.

Conclusion

The incidence of SPLC in survivors of certain primary cancers greatly exceeds the rate observed in the control arm of the NLST. Further study could help determine if screening for lung cancer in these cancer survivors could prevent death from lung cancer.

Keywords

SEER program Lung neoplasms Second primary neoplasms Epidemiology Survivors Screening 

Notes

Acknowledgements

This work was supported in part by the STOP Cancer Foundation and the Flax Family Foundation (KC).

Compliance with ethical standards

Conflict of interest

All authors report no financial conflicts of interest.

Informed consent

Dr. Nicholas M. Donin and Dr. Karim Chamie take ultimate responsibility for the integrity of the content contained herein.

Supplementary material

10552_2019_1161_MOESM1_ESM.docx (18 kb)
Supplementary material 1 (DOCX 18 KB)

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Nicholas M. Donin
    • 1
    • 3
    Email author
  • Lorna Kwan
    • 1
  • Andrew T. Lenis
    • 1
  • Alexandra Drakaki
    • 2
    • 3
  • Karim Chamie
    • 1
    • 3
  1. 1.Department of Urology, David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA
  2. 2.Department of Medicine, Division of Hematology & Oncology, David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA
  3. 3.Jonsson Comprehensive Cancer CenterUniversity of CaliforniaLos AngelesUSA

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