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Cancer Causes & Control

, Volume 23, Issue 12, pp 1911–1919 | Cite as

A history of allergies is associated with reduced risk of oral squamous cell carcinoma

  • Marni Stott-Miller
  • Chu Chen
  • David R. Doody
  • Joseph L. Carter
  • Denise A. Galloway
  • Margaret M. Madeleine
  • Stephen M. SchwartzEmail author
Original paper

Abstract

Purpose

A history of allergies is associated with a decreased risk of several types of cancers. Potential mechanisms include enhanced immune surveillance against tumor cells early in disease development and/or carcinogenic infectious agents. We tested whether allergies are inversely associated with oral squamous cell carcinoma (OSCC), accounting for factors that may modify the association, such as tumor site, stage, and HPV infection.

Methods

We estimated odds ratios (OR) and 95 % confidence intervals (CI) for the association between allergy history (including different types of allergies) and OSCC, adjusted for potential confounders, among 400 cases and 613 controls. Analyses were also stratified by site, stage, and measures of HPV infection.

Results

We observed a weak inverse association between history of any allergy and OSCC (OR = 0.81, 95 % CI 0.61–1.08). This association was present only for allergies to airborne allergens (dust/pollen/mold) (OR = 0.67; 95 % CI 0.48–0.93). The inverse associations with airborne allergies were slightly stronger for oropharyngeal SCC (OR = 0.56; 95 % CI 0.35–0.90) than for oral cavity SCC (OR = 0.71; 95 % CI 0.49–1.05) and present only for later-stage cancers (OR = 0.42; 95 % CI 0.26–0.66) as opposed to earlier-stage cancers (OR = 0.98; 95 % CI 0.66–1.46). Inverse associations were not particularly present or stronger among HPV-16-seropositive individuals or for HPV DNA-positive OSCC.

Conclusion

There is an inverse association between history of allergies to dust, pollen, or mold and OSCC. Whether the inverse association involves heightened immune surveillance, increased immune response to HPV or other antigen, or other carcinogenic mechanism remains to be determined in more definitive studies.

Keywords

Allergies Oral squamous cell carcinoma HPV HSV 

Notes

Acknowledgments

This work was supported by a fellowship (5T32DE007132-28) and research project grants (R01CA048896 and R01DE012609) from the United States NIH and institutional funds from the Fred Hutchinson Cancer Research Center.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Marni Stott-Miller
    • 1
    • 2
  • Chu Chen
    • 1
    • 2
    • 3
  • David R. Doody
    • 1
  • Joseph L. Carter
    • 1
  • Denise A. Galloway
    • 1
  • Margaret M. Madeleine
    • 1
    • 2
  • Stephen M. Schwartz
    • 1
    • 2
    Email author
  1. 1.Fred Hutchinson Cancer Research CenterSeattleUSA
  2. 2.Department of EpidemiologyUniversity of WashingtonSeattleUSA
  3. 3.Department of Otolaryngology-Head and Neck SurgeryUniversity of WashingtonSeattleUSA

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