Microtubule-associated tumor suppressors as prognostic biomarkers in breast cancer
Breast cancer is the most common malignancy in women worldwide. Although important therapeutic progress was achieved over the past decade, this disease remains a public health problem. In light of precision medicine, the identification of new prognostic biomarkers in breast cancer is urgently needed to stratify populations of patients with poor clinical outcome who may benefit from new personalized therapies. The microtubule cytoskeleton plays a pivotal role in essential cellular functions and is an interesting target for cancer therapy. Microtubule assembly and dynamics are regulated by a wide range of microtubule-associated proteins (MAPs), some of which have oncogenic or tumor suppressor effects in breast cancer.
This review covers current knowledge on microtubule-associated tumor suppressors (MATS) in breast cancer and their potential value as prognostic biomarkers. We present recent studies showing that combinatorial expression of ATIP3 and EB1, two microtubule-associated biomarkers with tumor suppressor and oncogenic effects, respectively, improves breast cancer prognosis compared to each biomarker alone.
These findings are discussed regarding the increasing complexity of protein networks composed of MAPs that coordinate microtubule dynamics and functions. Further studies are warranted to evaluate the prognostic value of combined expression of different MATS and their interacting partners in breast cancer.
KeywordsATIP3 Combinatorial expression EB1 Microtubule-associated protein Prognosis Tumor suppressor
This work has been funded by Gustave Roussy Cancer Center, the ANR Grant MMO ANR-10-IBHU-0001, the Comité Ile-de-France of the Ligue Nationale contre le Cancer, the Ligue contre le Cancer 94/Val-de-Marne, the Entreprises contre le cancer (GEFLUC) Ile-de-France, the Fondation ARC pour la recherche contre le cancer, the CNRS, the INSERM, the Fondation Janssen Horizon, the Fonds de Dotation Agnès b., the association Odyssea and Prolific.
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Conflict of interest
The authors declare that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
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