Advertisement

Breast Cancer Research and Treatment

, Volume 178, Issue 1, pp 161–167 | Cite as

National trends of synchronous bilateral breast cancer incidence in the United States

  • Takehiko Sakai
  • Enver Ozkurt
  • Stephen DeSantis
  • Stephanie M. Wong
  • Laurel Rosenbaum
  • Hui Zheng
  • Mehra GolshanEmail author
Epidemiology
  • 84 Downloads

Abstract

Purpose

Increase in breast cancer survivorship, advancements in diagnostic imaging and standardization of contralateral breast screening before breast cancer surgery have resulted in increased detection of contralateral breast cancer (CBC). The aim of this study was to assess national trends of synchronous bilateral breast cancer (sBBC) and metachronous bilateral breast cancer (mBBC) incidence in newly diagnosed breast cancer patients.

Methods

The Surveillance, Epidemiology, and End Results (SEER) database (1973–2014) was used to identify 11,177 women diagnosed with CBC. CBC was classified as sBBC when primary breast cancer in both breasts is diagnosed in the same year, or as mBBC, when diagnosed more than one year from primary breast cancer. Temporal trends in sBBC incidence were then evaluated using the Cochran-Armitage test for trend.

Results

Of the 11,177 women diagnosed with CBC, 4228 (38%) had sBBC and 6949 (62%) had mBBC. The incidence of sBBC increased significantly from 1.4% in 1975 to 2.9% in 2014 (p < 0.001). sBBC was more likely to be diagnosed as early stage in recent years (78% in 1975 vs. 90% in 2014 [p < 0.001]), and 69% of patients were treated with mastectomy in 2014.

Conclusion

The number of sBBC has increased, and contralateral tumors are more likely to be detected at an early stage with the first primary breast cancer. Despite the early stage findings, most were treated with mastectomy. Further studies are needed to define the best therapy for patients with contralateral disease and optimal surveillance and detection methods.

Keywords

Synchronous Metachronous Bilateral breast cancer Incidence Trends SEER 

Notes

Funding

No funding was used in the preparation, design, or writing of this paper.

Compliance with ethical standards

Conflict of interest

The authors have no conflict of interest to declare.

Ethical approval

This study was epidemiological study using de-identified data from the SEER database. Therefore, consent for patient participation and study publication was not required. Because this study did not meet the definition of human subject research, the protocol was considered exempt from review from the Dana-Farber Cancer Institute Institutional Review Board (DFCI Protocol No.: 18-034).

References

  1. 1.
    Siegel R, DeSantis C, Virgo K, Stein K, Mariotto A, Smith T, Cooper D, Gansler T, Lerro C, Fedewa S, Lin C, Leach C, Cannady RS, Cho H, Scoppa S, Hachey M, Kirch R, Jemal A, Ward E (2012) Cancer treatment and survivorship statistics. CA 62(4):220–241.  https://doi.org/10.3322/caac.21149 CrossRefPubMedGoogle Scholar
  2. 2.
    McCaul KA (2006) Bilateral breast cancer incidence and survival. [PhD thesis]. North Terrace, aDELAIDE SA 5005: University of Adelaide 2006. Available from: university of Adelaide. School of population Health and Clinical Practice, Library E-ReserveGoogle Scholar
  3. 3.
    AJCC cancer staging manual (2010). (7th ed). Springer, NYGoogle Scholar
  4. 4.
    van Ravesteyn NT, van Lier L, Schechter CB, Ekwueme DU, Royalty J, Miller JW, Near AM, Cronin KA, Heijnsdijk EA, Mandelblatt JS, de Koning HJ (2015) Transition from film to digital mammography: impact for breast cancer screening through the national breast and cervical cancer early detection program. Am J Prev Med 48(5):535–542.  https://doi.org/10.1016/j.amepre.2014.11.010 CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Knox M, O’Brien A, Szabo E, Smith CS, Fenlon HM, McNicholas MM, Flanagan FL (2015) Impact of full field digital mammography on the classification and mammographic characteristics of interval breast cancers. Eur J Radiol 84(6):1056–1061.  https://doi.org/10.1016/j.ejrad.2015.03.007 CrossRefPubMedGoogle Scholar
  6. 6.
    Howlader N NA, Krapcho M, Miller D, Bishop K, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds) SEER Cancer Statistics Review, 1975–2014, National Cancer Institute. Bethesda, MD, https://seer.cancer.gov/csr/1975_2014/, based on November 2016 SEER data submission, posted to the SEER web site, April 2017
  7. 7.
    Morrow M, Schmidt R, Hassett C (1995) Patient selection for breast conservation therapy with magnification mammography. Surgery 118(4):621–626CrossRefGoogle Scholar
  8. 8.
    Morrow M, Strom EA, Bassett LW, Dershaw DD, Fowble B, Giuliano A, Harris JR, O’Malley F, Schnitt SJ, Singletary SE, Winchester DP (2002) Standard for breast conservation therapy in the management of invasive breast carcinoma. CA 52(5):277–300PubMedGoogle Scholar
  9. 9.
    Tozaki M, Igarashi T, Fukuda K (2006) Positive and negative predictive values of BI-RADS-MRI descriptors for focal breast masses. Magn Reson Med Sci 5(1):7–15CrossRefGoogle Scholar
  10. 10.
    Lehman CD, Gatsonis C, Kuhl CK, Hendrick RE, Pisano ED, Hanna L, Peacock S, Smazal SF, Maki DD, Julian TB, DePeri ER, Bluemke DA, Schnall MD, Group ATI (2007) MRI evaluation of the contralateral breast in women with recently diagnosed breast cancer. N Engl J Med 356(13):1295–1303CrossRefGoogle Scholar
  11. 11.
    Wong SM, Freedman RA, Sagara Y, Aydogan F, Barry WT, Golshan M (2017) Growing use of contralateral prophylactic mastectomy despite no improvement in long-term survival for invasive breast cancer. Ann Surg 265(3):581–589.  https://doi.org/10.1097/SLA.0000000000001698 CrossRefPubMedGoogle Scholar
  12. 12.
    Yamauchi H, Okawa M, Yokoyama S, Nakagawa C, Yoshida R, Suzuki K, Nakamura S, Arai M (2018) High rate of occult cancer found in prophylactic mastectomy specimens despite thorough presurgical assessment with MRI and ultrasound: findings from the hereditary breast and ovarian cancer Registration 2016 in Japan. Breast Cancer Res Treat 172(3):679–687.  https://doi.org/10.1007/s10549-018-4953-1 CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    McLaughlin SA, Stempel M, Morris EA, Liberman L, King TA (2008) Can magnetic resonance imaging be used to select patients for sentinel lymph node biopsy in prophylactic mastectomy? Cancer 112(6):1214–1221.  https://doi.org/10.1002/cncr.23298 CrossRefPubMedGoogle Scholar
  14. 14.
    van Sprundel TC, Schmidt MK, Rookus MA, Brohet R, van Asperen CJ, Rutgers EJ, Van’t Veer LJ, Tollenaar RA (2005) Risk reduction of contralateral breast cancer and survival after contralateral prophylactic mastectomy in BRCA1 or BRCA2 mutation carriers. Br J Cancer 93(3):287–292.  https://doi.org/10.1038/sj.bjc.6602703 CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    Boughey JC, Khakpour N, Meric-Bernstam F, Ross MI, Kuerer HM, Singletary SE, Babiera GV, Arun B, Hunt KK, Bedrosian I (2006) Selective use of sentinel lymph node surgery during prophylactic mastectomy. Cancer 107(7):1440–1447.  https://doi.org/10.1002/cncr.22176 CrossRefPubMedGoogle Scholar
  16. 16.
    Yao K, Liederbach E, Tang R, Lei L, Czechura T, Sisco M, Howard M, Hulick PJ, Weissman S, Winchester DJ, Coopey SB, Smith BL (2015) Nipple-sparing mastectomy in BRCA1/2 mutation carriers: an interim analysis and review of the literature. Ann Surg Oncol 22(2):370–376.  https://doi.org/10.1245/s10434-014-3883-3 CrossRefPubMedGoogle Scholar
  17. 17.
    National Comprehensive Cancer Network. Development and update of the NCCN guidelines. Version 3.2018Google Scholar
  18. 18.
    NIH consensus conference Treatment of early-stage breast cancer (1991). JAMA 3:391-395Google Scholar
  19. 19.
    Frank TS, Deffenbaugh AM, Reid JE, Hulick M, Ward BE, Lingenfelter B, Gumpper KL, Scholl T, Tavtigian SV, Pruss DR, Critchfield GC (2002) Clinical characteristics of individuals with germline mutations in BRCA1 and BRCA2: analysis of 10,000 individuals. J Clin Oncol 20(6):1480–1490.  https://doi.org/10.1200/JCO.2002.20.6.1480 CrossRefPubMedGoogle Scholar
  20. 20.
    Couch FJ, DeShano ML, Blackwood MA, Calzone K, Stopfer J, Campeau L, Ganguly A, Rebbeck T, Weber BL (1997) BRCA1 mutations in women attending clinics that evaluate the risk of breast cancer. N Engl J Med 336(20):1409–1415.  https://doi.org/10.1056/NEJM199705153362002 CrossRefPubMedGoogle Scholar
  21. 21.
    Orvieto E, Maiorano E, Bottiglieri L, Maisonneuve P, Rotmensz N, Galimberti V, Luini A, Brenelli F, Gatti G, Viale G (2008) Clinicopathologic characteristics of invasive lobular carcinoma of the breast: results of an analysis of 530 cases from a single institution. Cancer 113(7):1511–1520.  https://doi.org/10.1002/cncr.23811 CrossRefPubMedGoogle Scholar
  22. 22.
    Li CI, Uribe DJ, Daling JR (2005) Clinical characteristics of different histologic types of breast cancer. Br J Cancer 93(9):1046–1052.  https://doi.org/10.1038/sj.bjc.6602787 CrossRefPubMedPubMedCentralGoogle Scholar
  23. 23.
    Mellemkjaer L, Steding-Jessen M, Frederiksen K, Andersson M, Ejlertsen B, Jensen MB et al (2014) Risk of contralateral breast cancer after tamoxifen use among Danish women. Ann Epidemiol 24(11):843–848.  https://doi.org/10.1016/j.annepidem.2014.08.003 CrossRefPubMedGoogle Scholar
  24. 24.
    Nichols HB, Berrington de González A, Lacey JV, Rosenberg PS, Anderson WF (2011) Declining incidence of contralateral breast cancer in the United States from 1975 to 2006. J Clin Oncol 29:1564–1569.  https://doi.org/10.1200/JCO.2010.32.7395 CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Takehiko Sakai
    • 1
    • 2
  • Enver Ozkurt
    • 1
    • 2
  • Stephen DeSantis
    • 2
  • Stephanie M. Wong
    • 1
    • 3
  • Laurel Rosenbaum
    • 1
  • Hui Zheng
    • 4
  • Mehra Golshan
    • 1
    • 2
    Email author
  1. 1.Division of Breast Surgery, Department of SurgeryBrigham and Women’s HospitalBostonUSA
  2. 2.Breast Oncology ProgramDana Farber/Brigham and Women’s Cancer CenterBostonUSA
  3. 3.McGill University Health CentreMontrealCanada
  4. 4.Biostatistics Center, Massachusetts General HospitalBostonUSA

Personalised recommendations