Breast Cancer Research and Treatment

, Volume 172, Issue 2, pp 265–272 | Cite as

Neoadjuvant therapy for breast cancer treatment: an expert panel recommendation from the Brazilian Society of Breast Surgeons 2018

  • Fernanda Barbosa C RochaEmail author
  • Ana Beatriz Falcone
  • Antonio Carlos Buzaid
  • Juliana Martins Pimenta
  • Gustavo Schvartsman
  • Antonio Luiz Frasson



Breast cancer neoadjuvant chemotherapy (NAC) consists of the administration of cytotoxic and targeted drugs prior to breast surgery, with the objective of reducing the tumor burden to allow breast conservation. NAC also aims to improve long-term treatment outcomes such as disease-free and overall survival. To optimize clinical practice with the best available evidence for breast cancer patients in the setting of neoadjuvant treatment, the Brazilian Society of Breast Surgeons (Sociedade Brasileira de Mastologia—SBM) held a consensus conference to develop this guideline.


Twenty-two questions addressing relevant breast cancer neoadjuvant treatment were previously formulated. The voting panel comprised 25 specialists from the SBM. A consensus was established if there was 75% agreement. If there was less concordance, after discussion, the consensus was determined by a 51% concordance.


The recommendations were based on the best level of scientific evidence and the opinion from breast cancer experts, when no such research data were available.


This manuscript provides updated guidance according to the views of the SBM’s experts for the clinical practice of breast cancer surgeons. This manuscript depicts the summarized recommendations for NAC treatment.


Breast cancer Neoadjuvant chemotherapy Recommendations Surgery Radiotherapy Treatment 



The authors wish to thank the support of Brazilian Society of Breast Surgeons and the panelists who voted and discussed the questions described in this manuscript: Antonio Fernando Melo Filho, Carlos Alberto Ruiz, Cícero de Andrade Urban, Darley de Lima Ferreira Filho, Diego Chaves Rezende Morais, Eduardo Camargo Millen, Fábio Bagnoli, Fabio Postiglione Mansani, Fabrício Palermo Brenelli, Felipe Pereira Zerwes, Francisco Pimentel Cavalcante, Glauber Moreira Leitão, José Francisco Rinaldi, José Luiz Pedrini, José Ricardo Conte de Souza, Linei Urban, Luciana Naíra de Brito Lima Limongi, Marcos Nolasco H. Neves, Maria do Carmo de Abreu e Lima, Mirela Ávila Gurgel, Mônica Vieira M. Travassos Jourdan, Paula Cristina Saab, Rafael Henrique Szymanski Machado, Régis Resende Paulinelli, and Ricardo Antonio Boff. The authors also wish to thank Felipe Ades, MD, PhD for providing medical writing on behalf of Springer Healthcare. This manuscript was prepared according to the International Society for Medical Publication Professionals’ Good Publication Practice for Communicating Company-Sponsored Medical Research: the GPP3 Guidelines. Funding to support the preparation of this manuscript was provided by Produtos Roche Químicos e Farmacêuticos S.A. The authors take full responsibility for the content and conclusions stated in this manuscript. Roche did not influence the content of this publication.

Compliance with ethical standards

Conflict of interest

Fernanda Barbosa Coelho Rocha, Ana Beatriz Falcone and Gustavo Schvartsman declared that they have no conflict of interest. Antonio Carlos Buzaid is a consultant and/or plays an advisory role at Roche, BMS, MSD, Pfizer, AstraZeneca, Esai, Novartis and Blau. Juliana Martins Pimenta is a consultant and/or plays an advisory role at Roche and Novartis. Antonio Luiz Frasson is a consultant and/or plays an advisory role at Roche.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Supplementary material

10549_2018_4912_MOESM1_ESM.docx (28 kb)
Supplementary material 1 (DOCX 27.554 KB)


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Hospital Israelita Albert EinsteinSão PauloBrazil
  2. 2.Instituto do Câncer do Estado de São Paulo (Icesp) – Faculdade de Medicina da Universidade de São Paulo (FMUSP)São PauloBrazil
  3. 3.Hospital Municipal Dr Cámino CaricchioSão PauloBrazil
  4. 4.Beneficência PortuguesaSão PauloBrazil
  5. 5.Escola de Medicina da Pontifícia Universidade Católica do Rio Grande do Sul (PUC-RS)Porto AlegreBrazil
  6. 6.Sociedade Brasileira de Mastologia (Gestão 2017-2019)Rio de JaneiroBrazil

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