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Breast Cancer Research and Treatment

, Volume 172, Issue 1, pp 113–121 | Cite as

Clinical subtypes and prognosis of pregnancy-associated breast cancer: results from the Korean Breast Cancer Society Registry database

  • Soo Youn Bae
  • Sei Joong Kim
  • JungSun Lee
  • Eun Sook Lee
  • Eun-Kyu Kim
  • Ho Young Park
  • Young Jin Suh
  • Hong Kyu Kim
  • Ji-Young You
  • Seung Pil Jung
Clinical trial

Abstract

Purpose

We analyzed the clinicopathologic characteristics and prognosis of pregnancy-associated breast cancer (PABC) according to clinical subtypes to better understand the characteristics of PABC.

Methods

A total of 83,792 female patients between the ages of 20 and 49 were enrolled in the Korean Breast Cancer Society Registry database from January 1, 1996 to December 31, 2015. ‘PABC’ is defined as breast cancer diagnosed during pregnancy or within 1 year after delivery. Other patients were defined as ‘non-PABC’ patients.

Results

In non-PABC patients, luminal A subtype was the most common (50.2%). In PABC patients, TNBC was the most common (40.4%) subtype, while luminal A comprised 21.2% and HER2 subtype comprised 17.3%. There was a significant difference in overall survival (OS). In non-PABC patients, TNBC had the highest HR (HR 2.3, 95% CI 2.1–2.6). In PABC patients, the luminal B subtype (HR+ HER2-high Ki67) had the highest HR at 7.0 (95% CI 1.7–29.1). In multivariate analysis of OS by subtypes, PABC patients had significantly higher HR than non-PABC patients in the HER2 subtype (HR 2.0, 95% CI 1.1–3.7) and luminal B subtype (HR+ HER2-high Ki67) (HR 4.4, 95% CI 1.6–12.3).

Conclusion

PABC showed different biologic features than non-PABC. PABC had a particularly poor prognosis in the luminal B (HR+ HER2-highKi67) and HER2 subtypes. To improve the prognosis of PABC, treatment should be considered according to subtype. Development of drugs that can be used during pregnancy is needed.

Keywords

Pregnancy Breast cancer Subtype Prognosis 

Notes

Acknowledgements

This work was supported by the Korean Breast Cancer Society. This work was supported by the National Research Foundation of Korea (2017R1D1A1B03028103) and Korea University Grant (K1813171).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

For this type of study informed consent is not required.

Supplementary material

10549_2018_4908_MOESM1_ESM.xlsx (13 kb)
Supplementary material 1 (XLSX 12 KB)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Soo Youn Bae
    • 1
  • Sei Joong Kim
    • 2
  • JungSun Lee
    • 3
  • Eun Sook Lee
    • 4
  • Eun-Kyu Kim
    • 5
  • Ho Young Park
    • 6
  • Young Jin Suh
    • 7
  • Hong Kyu Kim
    • 1
  • Ji-Young You
    • 1
  • Seung Pil Jung
    • 1
    • 8
  1. 1.Department of Surgery, Korea University Anam HospitalKorea University College of MedicineSeoulRepublic of Korea
  2. 2.Department of Surgery, Inha University HospitalInha University School of MedicineIncheonRepublic of Korea
  3. 3.Department of Surgery, Haeundae Paik Hospital, College of MedicineInje UniversityBusanRepublic of Korea
  4. 4.Center for Breast CancerNational Cancer CenterGoyang-siRepublic of Korea
  5. 5.Department of Surgery, Seoul National University Bundang HospitalSeoul National University College of MedicineGyeonggiRepublic of Korea
  6. 6.Department of Surgery, Kyungpook National University Medical CenterKyungpook National University School of MedicineDaeguRepublic of Korea
  7. 7.Division of Breast & Thyroid Surgical Oncology, Department of Surgery, College of Medicine, St. Vincent’s HospitalThe Catholic University of KoreaSuwonRepublic of Korea
  8. 8.Division of Breast and Endocrine Surgery, Department of Surgery, Korea University HospitalKorea University College of MedicineSeoulRepublic of Korea

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