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Breast Cancer Research and Treatment

, Volume 171, Issue 1, pp 217–223 | Cite as

Concurrent risk-reduction surgery in patients with increased lifetime risk for breast and ovarian cancer: an analysis of the National Surgical Quality Improvement Program (NSQIP) database

  • Maryam Elmi
  • Arash Azin
  • Ahmad Elnahas
  • David R. McCready
  • Tulin D. Cil
Epidemiology

Abstract

Background

Patients with genetic susceptibility to breast and ovarian cancer are eligible for risk-reduction surgery. Surgical morbidity of risk-reduction mastectomy (RRM) with concurrent bilateral salpingo-oophorectomy (BSO) is unknown. Outcomes in these patients were compared to patients undergoing RRM without BSO using a large multi-institutional database.

Methods

A retrospective cohort analysis was conducted using the American College of Surgeon’s National Surgical Quality Improvement Program (NSQIP) 2007–2016 datasets, comparing postoperative morbidity between patients undergoing RRM with patients undergoing RRM with concurrent BSO. Patients with genetic susceptibility to breast/ovarian cancer undergoing risk-reduction surgery were identified. The primary outcome was 30-day postoperative major morbidity. Secondary outcomes included surgical site infections, reoperations, readmissions, length of stay, and venous thromboembolic events. A multivariate analysis was performed to determine predictors of postoperative morbidity and the adjusted effect of concurrent BSO on morbidity.

Results

Of the 5470 patients undergoing RRM, 149 (2.7%) underwent concurrent BSO. The overall rate of major morbidity and postoperative infections was 4.5% and 4.6%, respectively. There was no significant difference in the rate of postoperative major morbidity (4.5% vs 4.7%, p = 0.91) or any of the secondary outcomes between patients undergoing RRM without BSO vs. those undergoing RRM with concurrent BSO. Multivariable analysis showed Body Mass Index (OR 1.05; p < 0.001) and smoking (OR 1.78; p = 0.003) to be the only predictors associated with major morbidity. Neither immediate breast reconstruction (OR 1.02; p = 0.93) nor concurrent BSO (OR 0.94; p = 0.89) were associated with increased postoperative major morbidity.

Conclusion

This study demonstrated that RRM with concurrent BSO was not associated with significant additional morbidity when compared to RRM without BSO. Therefore, this joint approach may be considered for select patients at risk for both breast and ovarian cancer.

Keywords

BRCA Genetic susceptibility Breast cancer Ovarian cancer National surgical quality improvement program Risk-reduction surgery Mastectomy Salpingo-oophorectomy 

Notes

Author contributions

ME, AA, AE, DRM, TDC: Conception and design, AE, AA: Acquisition of data, ME, AA, AE, DRM, TDC: Analysis and interpretation of data, ME, AA, AE, DRM, TDC: Drafting of manuscript, ME, AA, AE, DRM, TDC: Critical revision and final approval

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of SurgeryUniversity of TorontoTorontoCanada
  2. 2.Division of General SurgeryUniversity Health NetworkTorontoCanada
  3. 3.Department of SurgeryWomen’s College HospitalTorontoCanada
  4. 4.Department of SurgeryWestern UniversityLondonCanada

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