Treatment-induced early menopause and the protective role of gonadotropin-releasing hormone agonists during chemotherapy
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To the Editor,
We read with great interest the recently published article by Zhang and colleagues reporting the results of their randomized phase III trial investigating the efficacy and safety of concurrent versus sequential administration of chemotherapy and the gonadotropin-releasing hormone agonist (GnRHa) goserelin in premenopausal women with estrogen receptor-positive breast cancer . This study aimed at comparing the survival outcomes and the incidence of treatment-induced early menopause (defined as amenorrhea and postmenopausal levels of follicle-stimulating hormone and estradiol 1 year after the last GnRHa dose) between patients who received GnRHa for a duration of at least 2 years concurrently or sequentially to (neo)adjuvant chemotherapy. Among the 216 included patients, after a median follow-up of 56.9 months, no significant difference in disease-free survival (adjusted hazard ratio [HR] 1.52, 95% confidence intervals [CI] 0.80–2.86; p = 0.201) and overall survival...
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Conflict of interest
Matteo Lambertini acknowledges the support from the European Society for Medical Oncology (ESMO) for a Translational Research Fellowship at Institut Jules Bordet, Brussels, Belgium, and he served as a consultant for Teva outside the submitted work. The other authors declare no conflict of interest in relation to this article.
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