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Recovering Brain Dynamics During Concurrent tACS-M/EEG: An Overview of Analysis Approaches and Their Methodological and Interpretational Pitfalls

  • Florian H. Kasten
  • Christoph S. HerrmannEmail author
Review

Abstract

Transcranial alternating current stimulation (tACS) is increasingly used as a tool to non-invasively modulate brain oscillations in a frequency specific manner. A growing body of neuroscience research utilizes tACS to probe causal relationships between neuronal oscillations and cognitive processes or explore its capability of restoring dysfunctional brain oscillations implicated in various neurological and psychiatric disease. However, the underlying mechanisms of action are yet poorly understood. Due to a massive electromagnetic artifact, overlapping with the frequency of interest, direct insights to effects during stimulation from electrophysiological signals (i.e. EEG/MEG) are methodologically challenging. In the current review, we provide an overview of analysis approaches to recover brain signals in M/EEG during tACS, detailing their underlying concepts as well as limitations and methodological and interpretational pitfalls. While different analysis strategies can achieve strong attenuation of the tACS artifact in M/EEG signals, a compete removal of it is not feasible so far. However, we argue that with a combination of careful experimental designs, robust outcome measures and appropriate control analyses, valid and important insights to online effects of tACS can be revealed, enriching our understanding of its basic underlying mechanisms.

Keywords

Transcranial alternating current stimulation (tACS) Brain oscillations tACS-M/EEG integration Online effects MEG EEG 

Notes

Acknowledgements

Christoph S. Herrmann was supported by a Grant of the German Research Foundation (SPP, 1665 HE 3353/8-2).

Compliance with Ethical Standards

Conflict of interest

CSH holds a Patent on brain stimulation and received Honoraria as Editor from Elsevier Publishers, Amsterdam. FHK declares no competing interests.

Supplementary material

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Experimental Psychology Lab, Department of Psychology, Cluster for Excellence “Hearing for All”, European Medical SchoolCarl von Ossietzky UniversityOldenburgGermany
  2. 2.Neuroimaging Unit, European Medical SchoolCarl von Ossietzky UniversityOldenburgGermany
  3. 3.Research Center Neurosensory ScienceCarl von Ossietzky UniversityOldenburgGermany

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