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Altered Oscillatory Responses to Feedback in Borderline Personality Disorder are Linked to Symptom Severity

  • Paul Alexander Schauer
  • Jonas Rauh
  • Gregor Leicht
  • Christina Andreou
  • Christoph MulertEmail author
Original Paper

Abstract

Several studies using electroencephalography (EEG) demonstrate that the processing of feedback in patients suffering from borderline personality disorder (BPD) is altered in comparison to healthy controls. Differences occur in the theta (ca. 5 Hz) and high-beta frequency-ranges (ca. 20 Hz) of oscillations in response to negative and positive feedback, respectively. However, alpha (ca. 10 Hz) and low-beta (ca. 15 Hz) oscillations have also been shown to be involved in feedback processing. We hypothesized that additional alterations might occur in these frequency ranges in BPD. Eighteen patients with BPD and twenty-two healthy controls performed a gambling task while 64-channel-EEG was recorded. Induced oscillatory responses to positive (i.e. gain) and negative (i.e. loss) feedback in the alpha and low-beta frequency range were investigated. No significant differences were found in the alpha frequency range. Regarding the low-beta frequency range a significant Group (i.e. BPD vs. healthy controls) × Valence (i.e. gain vs. loss) interaction in the time frame between 600 and 700 milliseconds after feedback was found. This effect showed a significant correlation with symptom severity (assessed with the BSL-23). The results indicate that feedback processing in BPD could be more heavily altered than previously expected, with more severe symptomatology being linked to stronger alterations in oscillatory responses to feedback in the low-beta range.

Keywords

Feedback processing Borderline personality disorder Beta oscillations Symptom severity EEG sLORETA 

Notes

Acknowledgements

Parts of this work were prepared in the context of P Schauers doctoral dissertation at the Faculty of Medicine, University of Hamburg, Germany. Special thanks to Julia Kleinert for her preparatory work.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Paul Alexander Schauer
    • 1
  • Jonas Rauh
    • 1
  • Gregor Leicht
    • 1
  • Christina Andreou
    • 1
    • 2
  • Christoph Mulert
    • 1
    • 3
    Email author
  1. 1.Psychiatry Neuroimaging Branch, Department of Psychiatry and PsychotherapyUniversity Medical Center Hamburg EppendorfHamburgGermany
  2. 2.Center for Gender Research and Early DetectionUniversity of Basel Psychiatric ClinicsBaselSwitzerland
  3. 3.Department of Psychiatry and Psychotherapy, UKGMJustus-Liebig University GiessenGiessenGermany

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