Brain Topography

, Volume 31, Issue 3, pp 468–476 | Cite as

Decreased Metabolism in the Posterior Medial Network with Concomitantly Increased Metabolism in the Anterior Temporal Network During Transient Global Amnesia

  • SangHak Yi
  • Young Ho Park
  • Jae-Won Jang
  • Jae-Sung Lim
  • In Kook Chun
  • SangYun Kim
Original Paper
  • 77 Downloads

Abstract

Perturbation of corticohippocampal circuits is a key step in the pathogenesis of transient global amnesia. We evaluated the spatial distribution of altered cerebral metabolism to determine the location of the corticohippocampal circuits perturbed during the acute stage of transient global amnesia. A consecutive series of 12 patients with transient global amnesia who underwent 18F-fluorodeoxyglucose positron emission tomography within 3 days after symptom onset was identified. We used statistical parametric mapping with two contrasts to identify regions of decreased and increased brain metabolism in transient global amnesia patients compared with 25 age-matched controls. Transient global amnesia patients showed hypometabolic clusters in the left temporal and bilateral parieto-occipital regions that belong to the posterior medial network as well as, hypermetabolic clusters in the bilateral inferior frontal regions that belong to the anterior temporal network. The posterior medial and anterior temporal networks are the two main corticohippocampal circuits involved in memory-guided behavior. Decreased metabolism in the posterior medial network might explain the impairment of episodic memory observed during the acute stage of transient global amnesia. Concomitant increased metabolism within the anterior temporal network might occur as a compensatory mechanism.

Keywords

Hippocampus Positron emission tomography Anterior temporal network Posterior medial network Transient global amnesia 

Notes

Compliance with Ethical Standards

Conflict of interest

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Ethical Approval

The study protocol was approved by the Institutional Review Board of Seoul National University Bundang Hospital. Informed consent was not required due to the retrospective nature of the study and minimal risk to participants.

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • SangHak Yi
    • 1
  • Young Ho Park
    • 2
  • Jae-Won Jang
    • 3
  • Jae-Sung Lim
    • 4
  • In Kook Chun
    • 5
  • SangYun Kim
    • 2
  1. 1.Department of NeurologyWonkwang University School of Medicine and Regional Cardiocerebrovascular CenterIksan-siSouth Korea
  2. 2.Department of Neurology, Seoul National University College of Medicine and Clinical Neuroscience CenterSeoul National University Bundang HospitalSeongnam-siSouth Korea
  3. 3.Department of Neurology, School of MedicineKangwon National UniversityChuncheon-siSouth Korea
  4. 4.Department of NeurologyHallym University Sungim HospitalAnyang-siSouth Korea
  5. 5.Department of Nuclear Medicine, School of MedicineKangwon National UniversityChuncheon-siSouth Korea

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