Biomedical Microdevices

, 21:93 | Cite as

Microfluidic devices with gold thin film channels for chemical and biomedical applications: a review

  • Mahtab Ghasemi Toudeshkchoui
  • Navid Rabiee
  • Mohammad Rabiee
  • Mojtaba Bagherzadeh
  • Mohammadreza TahririEmail author
  • Lobat Tayebi
  • Michael R. HamblinEmail author


Microfluidic systems (MFS) provide a range of advantages in biomedical applications, including improved controllability of material characteristics and lower consumption of reagents, energy, time and money. Fabrication of MFS employs various materials, such as glass, silicon, ceramics, paper, and metals such as gold, copper, aluminum, chromium and titanium. In this review, gold thin film microfluidic channels (GTFMFC) are discussed with reference to fabrication methods and their diverse use in chemical and biomedical applications. The advantages of gold thin films (GTF) include flexibility, ease of manufacture, adhesion to polymer surfaces, chemical stability, good electrical conductivity, surface plasmon resonance effects, ability to be chemically functionalized, etc. Various electroactuators and electroanalytical devices can incorporate GTF. GTF-based MFS have been used in environmental monitoring, assays of biomarkers, immunoassays, cell culture studies and pathogen identification.


Microfluidic systems Gold thin film channels Biomedical applications Surface plasmonic resonance Electrochemical sensors 


Funding information

MRH was supported by US NIH Grants R01AI050875 and R21AI121700.

Compliance with ethical standards

Conflict of interest

MRH declares the following potential conflicts of interest. Scientific Advisory Boards: Transdermal Cap Inc., Cleveland, OH; BeWell Global Inc., Wan Chai, Hong Kong; Hologenix Inc. Santa Monica, CA; LumiThera Inc., Poulsbo, WA; Vielight, Toronto, Canada; Bright Photomedicine, Sao Paulo, Brazil; Quantum Dynamics LLC, Cambridge, MA; Global Photon Inc., Bee Cave, TX; Medical Coherence, Boston MA; NeuroThera, Newark DE; JOOVV Inc., Minneapolis-St. Paul MN; AIRx Medical, Pleasanton CA; FIR Industries, Inc. Ramsey, NJ; UVLRx Therapeutics, Oldsmar, FL; Ultralux UV Inc., Lansing MI; Illumiheal & Petthera, Shoreline, WA; MB Lasertherapy, Houston, TX; ARRC LED, San Clemente, CA; Varuna Biomedical Corp. Incline Village, NV; Niraxx Light Therapeutics, Inc., Boston, MA. Consulting; Lexington Int, Boca Raton, FL; USHIO Corp, Japan; Merck KGaA, Darmstadt, Germany; Philips Electronics Nederland B.V. Eindhoven, Netherlands; Johnson & Johnson Inc., Philadelphia, PA; Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, Germany. Stockholdings: Global Photon Inc., Bee Cave, TX; Mitonix, Newark, DE.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.School of Chemical Engineering, College of EngineeringUniversity of TehranTehranIran
  2. 2.Department of ChemistrySharif University of TechnologyTehranIran
  3. 3.Biomaterial Group, Department of Biomedical EngineeringAmirkabir University of TechnologyTehranIran
  4. 4.Department of Developmental SciencesMarquette UniversityMilwaukeeUSA
  5. 5.Wellman Center for PhotomedicineMassachusetts General HospitalBostonUSA
  6. 6.Department of DermatologyHarvard Medical SchoolBostonUSA
  7. 7.Harvard-MIT Division of Health Sciences and TechnologyCambridgeUSA

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