Polymers for extended-release administration
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Developing strategies to deliver the required dose of therapeutics into target tissues and cell populations within the body is a principal aim of controlled release and drug delivery. Specifically, there is an interest in developing formulations that can achieve drug concentrations within the therapeutic window, for extended periods of time, with tunable release profiles, and with minimal complication and distress for the patient. To date, drug delivery systems have been developed to serve as depots, triggers, and carriers for therapeutics including small molecules, biologics, and cell-based therapies. Notably, the efficacy of these systems is intricately tied to the manner in which they are administered. For example, systemic and oral routes of administration are common, but both can result in rapid clearance from the organism. Towards this end, what formulation and administration route strategies are available to prolong the bioavailability of therapeutics? Here, we discuss historical and modern drug delivery systems, with the intention of exploring how properties including formulation, administration route and chemical structure influence the ability to achieve extended-release drug release profiles within the body.
KeywordsControlled release system Drug delivery Extended release Polymer
We would like to congratulate Professor Mauro Ferrari on the occasion of his 60th birthday for his impactful scientific career and his contributions to the field of bioengineering. Some of us were fortunate enough to have the opportunity to attend a lecture he gave at MIT in February 2018. Professor Ferrari’s talk was creative and exciting, and his approach to science, management, and culture was truly inspiring. Congratulations Professor Ferrari and we wish you the happiest of birthdays.
- S.D. Anker et al., A prospective comparison of alginate-hydrogel with standard medical therapy to determine impact on functional capacity and clinical outcomes in patients with advanced heart failure (AUGMENT-HF trial). Eur. Heart J. 36(34), 2297–2309 (2015). https://doi.org/10.1093/eurheartj/ehv259 CrossRefGoogle Scholar
- E.A. Appel et al., ‘Self-assembled hydrogels utilizing polymer-nanoparticle interactions’, Nat. Commun. Nature Publishing Group, 6, pp. 1–9 (2015). doi: https://doi.org/10.1038/ncomms7295.
- A.K. Bajpai et al., ‘Responsive polymers in controlled drug delivery’, Prog. Polym. Sci. Oxford., pp. 1088–1118 (2008). doi: https://doi.org/10.1016/j.progpolymsci.2008.07.005.CrossRefGoogle Scholar
- C. Buttorff, T. Ruder, M. Bauman, Multiple Chronic Conditions in the United States. (2017). doi: https://doi.org/10.7249/TL221.
- Deloitte (2018) ‘2018 Global life sciences outlook Innovating life sciences in the fourth industrial revolution: Embrace, build, grow’.Google Scholar
- L. Dong et al., A pH/enzyme-responsive tumor-specific delivery system for doxorubicin. Biomaterials 31(24), 6309–6316 (2010). https://doi.org/10.1016/j.biomaterials.2010.04.049 CrossRefGoogle Scholar
- G.H. Gao et al., The use of pH-sensitive positively charged polymeric micelles for protein delivery. Biomaterials 33(35), 9157–9164 (2012). https://doi.org/10.1016/j.biomaterials.2012.09.016 CrossRefGoogle Scholar
- M. Germain et al., ‘Priming the body to receive the therapeutic agent to redefine treatment benefit/risk profile’, Sci. Rep., 8(1) (2018). doi: https://doi.org/10.1038/s41598-018-23140-9.
- K. Ghasemi Falavarjani, Implantable posterior segment drug delivery devices; novel alternatives to currently available treatments. J. Ophthalmic Vis. Res.. Wolters Kluwer -- Medknow Publications 4(3), 191–193 (2009)Google Scholar
- G. Gu et al., PEG-co-PCL nanoparticles modified with MMP-2/9 activatable low molecular weight protamine for enhanced targeted glioblastoma therapy. Biomaterials 34(1), 196–208 (2013a). https://doi.org/10.1016/j.biomaterials.2012.09.044 CrossRefGoogle Scholar
- A.S. Hoffman, P.S. Stayton, Conjugates of stimuli-responsive polymers and proteins. Prog. Polym. Sci. (Oxford) 32, 922–932 (2007). https://doi.org/10.1016/j.progpolymsci.2007.05.005 CrossRefGoogle Scholar
- M.R. Hoy and E.J. Roche (1993) Taste mask coatings for preparation of chewable pharmaceutical tablets.Google Scholar
- B. Jeong, A. Gutowska, ‘Lessons from nature: Stimuli-responsive polymers and their biomedical applications’, Trends Biotechnol., pp. 305–311 (2002). doi: https://doi.org/10.1016/S0167-7799(02)01962-5,20.
- B.A. Johnson, Naltrexone long-acting formulation in the treatment of alcohol dependence. Ther. Clin. Risk Manag.. Dove Press 3(5), 741–749 (2007)Google Scholar
- M. Kastellorizios, F. Papadimitrakopoulos, D.J. Burgess, Multiple tissue response modifiers to promote angiogenesis and prevent the foreign body reaction around subcutaneous implants. J. Control. Release Elsevier B.V. 214, 103–111 (2015). https://doi.org/10.1016/j.jconrel.2015.07.021 CrossRefGoogle Scholar
- D. Klinger, K. Landfester, Dual stimuli-responsive poly(2-hydroxyethyl methacrylate-co-methacrylic acid) microgels based on photo-cleavable cross-linkers: PH-dependent swelling and light-induced degradation. Macromolecules 44(24), 9758–9772 (2011). https://doi.org/10.1021/ma201706r CrossRefGoogle Scholar
- D. Lalka, R.K. Griffith, C.L. Cronenberger, The hepatic first-pass metabolism of problematic drugs. J. Clin. Pharmacol. 33(7), 657–669 (1993). https://doi.org/10.1002/j.1552-4604.1993.tb04720.x CrossRefGoogle Scholar
- D.G. Leach et al., STINGel: Controlled release of a cyclic dinucleotide for enhanced cancer immunotherapy. Biomaterials. Elsevier Ltd 163, 67–75 (2018). https://doi.org/10.1016/j.biomaterials.2018.01.035 CrossRefGoogle Scholar
- H. Lee et al., A photo-degradable gene delivery system for enhanced nuclear gene transcription. Biomaterials 35(3), 1040–1049 (2014). https://doi.org/10.1016/j.biomaterials.2013.10.030 CrossRefGoogle Scholar
- M.S. Lesniak, H. Brem, Targeted therapy for brain Tumours. Nat. Rev. Drug Discov. 3(June), 499–508 (2004). https://doi.org/10.1016/B978-0-12-397927-8.00005-1. CrossRefGoogle Scholar
- J. Li, D.J. Mooney, Designing hydrogels for controlled drug delivery. Nat. Rev. Mater. 1(12) (2016). https://doi.org/10.1038/natrevmats.2016.71
- F. Liu, M.W. Urban, Recent advances and challenges in designing stimuli-responsive polymers. Prog. Polym. Sci. 35(1–2), 3–23 (2010). https://doi.org/10.1016/j.progpolymsci.2009.10.002. CrossRefGoogle Scholar
- Y. Lu et al., Bioresponsive materials. Nat. Rev. Mater. 2(1) (2016). https://doi.org/10.1038/natrevmats.2016.75
- C.E. Markwalter, R.K. Prud’homme, Design of a Small-Scale Multi-Inlet Vortex Mixer for scalable nanoparticle production and application to the encapsulation of biologics by inverse flash NanoPrecipitation. J. Pharm. Sci.. Elsevier Ltd 107, 1–7 (2018). https://doi.org/10.1016/j.xphs.2018.05.003 CrossRefGoogle Scholar
- D.F. Martin et al., Treatment of cytomegalovirus retinitis with an intraocular sustained-release Ganciclovir implant. Arch. Ophthalmol. American Medical Association 112(12), 1531 (1994). https://doi.org/10.1001/archopht.1994.01090240037023 CrossRefGoogle Scholar
- T.G. Park, W. Lu, G. Crotts, Importance of in vitro experimental conditions on protein release kinetics, stability and polymer degradation in protein encapsulated poly (d,l-lactic acid-co-glycolic acid) microspheres. J. Control. Release 33(2), 211–222 (1995). https://doi.org/10.1016/0168-3659(94)00084-8 CrossRefGoogle Scholar
- M.R. Prausnitz, Engineering microneedle patches for vaccination and drug delivery to skin. Annual Rev Chem Biomolecular Eng 8(1), 177–200 (2017). https://doi.org/10.1146/annurev-chembioeng-060816-101514 CrossRefGoogle Scholar
- N.G. Rouphael et al., The safety, immunogenicity, and acceptability of inactivated influenza vaccine delivered by microneedle patch (TIV-MNP 2015): A randomised, partly blinded, placebo-controlled, phase 1 trial. Lancet 390(10095), 649–658 (2017). https://doi.org/10.1016/S0140-6736(17)30575-5 CrossRefGoogle Scholar
- S. Rowlands, D. Mansour, M. Walling, Intravascular migration of contraceptive implants: Two more cases. Contraception. Elsevier 95(2), 211–214 (2017). https://doi.org/10.1016/j.contraception.2016.07.015 CrossRefGoogle Scholar
- B.B. Seo et al., The biological efficiency and bioavailability of human growth hormone delivered using injectable, ionic, thermosensitive poly(organophosphazene)-polyethylenimine conjugate hydrogels. Biomaterials. Elsevier Ltd 32(32), 8271–8280 (2011). https://doi.org/10.1016/j.biomaterials.2011.07.033 CrossRefGoogle Scholar
- L. Serra, J. Doménech, N.A. Peppas, Drug transport mechanisms and release kinetics from molecularly designed poly(acrylic acid-g-ethylene glycol) hydrogels. Biomaterials 27(31), 5440–5451 (2006). https://doi.org/10.1016/j.biomaterials.2006.06.011 CrossRefGoogle Scholar