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Biomedical Microdevices

, 21:25 | Cite as

A novel and reproducible release mechanism for a drug-delivery system in the gastrointestinal tract

  • Xudong GuoEmail author
  • Zhongyu Luo
  • Haipo Cui
  • Jing Wang
  • Qinfen Jiang
Article
  • 67 Downloads

Abstract

To establish a reliable, reproducible and accurate release of the drug in the gastrointestinal tract, a novel release mechanism for a controllable drug-delivery system has been investigated. The release mechanism, consisting of a one-way valve for drug release, a drug chamber, two axially magnetized cylindrical permanent magnets and a multi-layer solenoid coil, is hosted in the capsule-shaped shell with diameter 11 mm and length 30 mm. To actuate the coil piston, the two static magnetic fields produced by the two magnets are aligned along the same axis, having the same magnitude, but opposite directions. Based on the principle of the electromagnetic force and the Bernoulli equation, the actuating force can be expressed as a function of the coil stroke and the excitation current, which was modeled and experimentally verified. Thus the actuating force can be controlled by adjusting the activated period and intensity of the coil, resulting in the reproducible release with different doses and mean rates. Then, a prototype of the drug-delivery system has been developed, which consists of a drug-delivery capsule, a radio frequency transmission module, an interface circuit, and an instruction setting and triggering platform. All the drug release parameters, including the release mode, times, dose and mean flow rate, can be set by the platform. The experiment verifies that the drug-delivery capsule can deliver a predetermined dose with different flow rates and dip angles of the capsule. The relative error of the releasing dose becomes larger with increasing releasing rate and decreasing releasing dose.

Keywords

Drug-delivery systems Release mechanisms Electromagnetic actuating force Reproducible and accurate release 

Notes

Acknowledgments

This work was supported by Natural Science Foundation of Shanghai [grant number 15ZR1428200]; and the National Natural Science Foundation of China [grant number 61001164].

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.School of Medical Instrument and Food EngineeringUniversity of Shanghai for Science and TechnologyShanghaiChina
  2. 2.Jiangsu Apon Medical Technology Co., LTDNantongChina
  3. 3.Department of Information Technology, East HospitalTongji University School of MedicineShanghaiChina

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