Coupling tumor growth and bio distribution models
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We couple a tumor growth model embedded in a microenvironment, with a bio distribution model able to simulate a whole organ. The growth model yields the evolution of tumor cell population, of the differential pressure between cell populations, of porosity of ECM, of consumption of nutrients due to tumor growth, of angiogenesis, and related growth factors as function of the locally available nutrient. The bio distribution model on the other hand operates on a frozen geometry but yields a much refined distribution of nutrient and other molecules. The combination of both models will enable simulating the growth of a tumor in a whole organ, including a realistic distribution of therapeutic agents and allow hence to evaluate the efficacy of these agents.
KeywordsModeling Multiphase Biodistribution Code coupling Angiogenesis Smearded finite element
B.A.S. gratefully acknowledges the support of the Technische Universität München - Institute for Advanced Study, funded by the German Excellence Initiative and the TUV SÜD Foundation. The authors acknowledge CITO Award, Houston Methodist Research Institute, Houston, NCI U54 CA210181. The authors affiliated to Serbian institutions also acknowledge support from Ministry of Education and Science of Serbia, grants OI 174028 and III 41007, and City of Kragujevac.
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