Biology & Philosophy

, 34:14 | Cite as

Lamarckian realities: the CRISPR-Cas system and beyond

  • Eva JablonkaEmail author


In his target article, Koonin discusses the insights into the evolution of bacterial genomes provided by the CRISPR-Cas system. This evolved defense system is based on intrinsic processes of genome engineering which, as he argues, enable Lamarckian inheritance. In this commentary I discuss some historical and conceptual issues that pertain to Koonin’s analysis of this aspect of the CRISPR-Cas system, extending and qualifying his discussion.


CRISPR-Cas Defense system Genome engineering Lamarckian inheritance 


  1. Beisson J, Sonneborn TM (1965) Cytoplasmic inheritance of the organization of the cell cortex in Paramecium aurelia. Proc Natl Acad Sci USA 53:275–282CrossRefGoogle Scholar
  2. Bestor TH (1990) DNA methylation: evolution of a bacterial immune function into a regulator of gene expression and genome structure in higher eukaryotes. Philos Trans R Soc Lond B Biol Sci 326:179–187CrossRefGoogle Scholar
  3. Dawkins R (1982) The extended phenotype. The gene as the unit of selection. W.H. Freeman and Company, OxfordGoogle Scholar
  4. Gissis S, Jablonka E (eds) (2011) The transformations of lamarckism: from subtle fluids to molecular biology. MIT Press, CambridgeGoogle Scholar
  5. Jablonka E, Lamb MJ (1995) Epigenetic inheritance and evolution—the Lamarckian dimension. Oxford University Press, OxfordGoogle Scholar
  6. Jablonka E, Lamb MJ (2014) Evolution in four dimensions. Genetic, epigenetic, behavioral and symbolic variation in the history of life (second revised edition). MIT Press, CambridgeGoogle Scholar
  7. Jablonka E, Lamb MJ, Avital E (1998) Lamarckian mechanisms in Darwinian evolution. Trends Ecol Evol 13:206–210CrossRefGoogle Scholar
  8. Lachman M, Jablonka E (1996) The inheritance of phenotypes: an adaptation to fluctuating environment. J Theor Biol 181:1–9CrossRefGoogle Scholar
  9. Lamarck JB (1809) Philosophie zoologique, ou Exposition des considérations relatives à l’histoire naturelle des animaux. Dentu, Paris. English translation by Elliot H (1914), Zoological philosophy: an exposition with regard to the natural history of animals. Macmillan, London. Reprinted by University of Chicago Press, 1984Google Scholar
  10. Lamm E, Jablonka E (2008) The nurture of nature: hereditary plasticity in evolution. Philos Psychol 21:305–319CrossRefGoogle Scholar
  11. Mayr E (1982) The growth of biological thought: diversity, evolution, and inheritance. Harvard University Press, CambridgeGoogle Scholar
  12. Regev A, Lamb MJ, Jablonka E (1998) The role of DNA methylation in invertebrates: developmental regulation or genome defense? Mol Biol Evol 15:880–891CrossRefGoogle Scholar
  13. Weiss A (2015) Lamarckian illusions. Trends Ecol Evol 30:566–568CrossRefGoogle Scholar

Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.The Cohn Institute for the History and Philosophy of Science and IdeasTel Aviv UniversityTel AvivIsrael
  2. 2.Sagol School of NeuroscienceTel Aviv UniversityTel AvivIsrael

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