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BioMetals

, Volume 32, Issue 2, pp 185–193 | Cite as

Biodegradable magnesium alloys as temporary orthopaedic implants: a review

  • Sepideh KamraniEmail author
  • Claudia Fleck
Article
  • 327 Downloads

Abstract

The study of innovative biodegradable implant materials is one of the most interesting research topics at the forefront in the area of biomaterials. Biodegradable implant materials in the human body can be gradually dissolved, absorbed, consumed or excreted, so there is no need for the secondary surgery to remove implants after the surgery regions have healed. However, most of the biodegradable materials, usually polymers, do not have good mechanical properties to be reliable for bearing the load of the body. Magnesium and its alloys due to the excellent biodegradability and biocompatibility as well as the suitable mechanical compatibility with human bone are very promising candidates for the development of temporary, degradable implants in load-bearing applications. However, Mg alloys are corrosion susceptible in a biological environment. Besides, the high corrosion rate and the low bioactivity of magnesium implants are the challenging problems, which need to be resolved before employing them in clinical applications. This paper provides a review of state-of-the-art of magnesium alloy implants for orthopedic and tissue engineering applications and describes recent progress in the design of novel structure design Mg alloys and potential approaches to improve their biodegradation performance.

Keywords

Magnesium Biomaterial Biodegradable Temporary implant 

Notes

Acknowledgements

The authors would like to thank Department of Materials Engineering, Institute of Technology Berlin for the extremely helpful guidance in carrying out the review paper and providing them with the appropriate data required.

References

  1. Birbilis N, Ralston KD, Virtanen S, Fraser HL, Davies CHJ (2010) Grain character influences on corrosion of ECAPed pure magnesium. Corros Eng, Sci Technol 45(3):224–230CrossRefGoogle Scholar
  2. Bostman O, Viljanen J, Salminen S, Pihlajamaki H (2000) Response of articular cartilage and subchondral bone to internal fixation devices made of poly-L-lactide: a histomorphometric and microradiographic study on rabbits. Biomaterials 21:2553–2560CrossRefGoogle Scholar
  3. Chen K, Dai J, Zhang X (2015) Improvement of corrosion resistance of magnesium alloys for biomedical applications. Corros Rev 33:101–117CrossRefGoogle Scholar
  4. Choudhary L, Raman RK (2012) Magnesium alloys as body implants: fracture mechanism under dynamic and static loadings in a physiological environment. Acta Biomater 8:916–923CrossRefGoogle Scholar
  5. Choudhary L, Raman RKS (2013) Microstructure mechanical property and in vitro biocorrosion behavior of single-phase biodegradable Mg-1.5 Zn-0.6 Zr alloy. Eng Fract Mech 103:94–102CrossRefGoogle Scholar
  6. Clemow JT, Weinstein AM, Klawitter JJ, Koeneman J, Anderson J (1981) Interface mechanics of porous titanium implants. J Biomed Mater Res 15:73–82CrossRefGoogle Scholar
  7. Daoud A, El-khair MTA, Abdel-Aziz M, Rohatgi P (2007) Fabrication, microstructure and compressive behavior of ZC63 Mg–microballoon foam composites. Compos Sci Technol 67:1842–1853CrossRefGoogle Scholar
  8. Davies JR (2003) Metallic materials in handbook of materials for medical devices. ASM International, Materials Park, pp 21–50Google Scholar
  9. Feng A, Han Y (2010) The microstructure, mechanical and corrosion properties of calcium polyphosphate reinforced ZK60A magnesium alloy composites. J Alloys Compds 504:585–593CrossRefGoogle Scholar
  10. Feng A, Han Y (2011) Mechanical and in vitro degradation behavior of ultrafine calcium polyphosphate reinforced magnesium-alloy composites. Mater Des 32:2813–2820CrossRefGoogle Scholar
  11. Frost HM (1989) The biology of fracture healing. An overview for clinicians. Part I. Clin Orthop Relat Res 248:283–293Google Scholar
  12. González S et al. (2013) Biodegradation and mechanical integrity of magnesium and magnesium alloys suitable for implants, Chapter 12Google Scholar
  13. Gu XN, Zheng YF (2010) A review on magnesium alloys as biodegradable materials. Front Mater Sci China 4:111–115CrossRefGoogle Scholar
  14. Gu XN, Zhou W, Zheng Y, Cheng Y, Wei S, Zhong S, Xi TF, Chen LJ (2010a) Corrosion fatigue behaviors of two biomedical Mg alloys—AZ91D and WE43—in simulated body fluid. Acta Biomater 6:4605–4613CrossRefGoogle Scholar
  15. Gu X, Zhou W, Zheng Y, Liu Y, Li Y (2010b) Degradation and cytotoxicity of lotus-type porous pure magnesium as potential tissue engineering scaffold material. Mater Lett 64:1871–1874CrossRefGoogle Scholar
  16. Gu XN, Zhou WR, Zheng YF, Dong LM, Xi YL, Chai DL (2010c) Microstructure, mechanical property, bio-corrosion and cytotoxicity evaluations of Mg/HA composites. Mater Sci Eng, C 30:827–832CrossRefGoogle Scholar
  17. Hiromoto S, Tomozawa M, Maruyama N (2013) Fatigue property of a bioabsorbabale magnesium alloy with a hydroxyapatite coating formed by a chemical solution deposition. J Mech Behav Biomed Mater 25:1–10CrossRefGoogle Scholar
  18. Hornberger H, Virtanen S, Boccaccini AR (2012) Biomedical coatings on magnesium alloys—a review. Acta Biomater 8:2442–2455CrossRefGoogle Scholar
  19. Hou LD, Li Z, Pan Y, Du L, Li XL, Zheng YF, Li L (2014) In vitro and in vivo studies on biodegradable magnesium alloy. Prog Nat Sci 24:466–471CrossRefGoogle Scholar
  20. Jacobs JJ, Gilbert JL, Urban RM (1998) Corrosion of metal orthopaedic implants. J Bone Joint Surg 80:268–282CrossRefGoogle Scholar
  21. Jacobs JJ, Hallab NJ, Skipor AK, Urban RM (2003) Metal degradation products: a cause for concern in metal-metal bearings? Clin Orthop Relat Res 417:139–147Google Scholar
  22. Jafari S, Singh Raman RK, Davies CHJ (2015) Corrosion fatigue of a magnesium alloy in modified simulated body fluid. Eng Fract Mech 137:2–11CrossRefGoogle Scholar
  23. Jai Poinern GE, Brundavanam S, Fawcett D (2012) Biomedical magnesium alloys: a review of material properties, surface modifications and potential as a biodegradable orthopaedic implant. Am J Biomed Eng 2(6):218–240CrossRefGoogle Scholar
  24. Jang Y, Collins B, Sankar J, Yun Y (2013) Effect of biologically relevant ions on the corrosion products formed on alloy AZ31B: an improved understanding of magnesium corrosion. Acta Biomaterial 9:8761–8770CrossRefGoogle Scholar
  25. Jasmawati N, Djuansjah JRP, Kadir MRA, Sukmana I (2015) Porous magnesium scaffolds for bone implant applications: a review. Adv Mater Res 1125:437–440CrossRefGoogle Scholar
  26. Kannan MB (2010) Influence of microstructure on the in vitro degradation behaviour of magnesium alloy. Mater Lett 64:739–742CrossRefGoogle Scholar
  27. Kannan MB, Raman RKS (2008) Stress corrosion cracking of magnesium alloys. Scripta Mater 59:175–178CrossRefGoogle Scholar
  28. Kannan M, Raman R, Witte F, Blawert C, Dietzel W (2011) Influence of circumferential notch and fatigue crack on the mechanical integrity of biodegradable magnesium-based alloy in simulated body fluid. J Biomed Mater Res, Part B 96:303–309CrossRefGoogle Scholar
  29. Khanra AK, Jung HC, Hong KS, Shin KS (2010) Comparative property study on extruded Mg-HAP and ZM61-HAP composites. Mater Sci Eng, A 527:6283–6288CrossRefGoogle Scholar
  30. Kraus T, Fischerauer S, Hänzi A, Uggowitzer P, Löffler J, Weinberg AM (2012) Magnesium alloys for temporary implants in osteosynthesis: in vivo studies of their degradation and interaction with bone. Acta Biomateriala 8:1230–1238CrossRefGoogle Scholar
  31. Lefebvre LP, Banhart J, Dunand D (2008) Porous metals and metallic foams: current status and recent developments. Adv Eng Mater 10:775–787CrossRefGoogle Scholar
  32. Lhotka C, Szekeres T, Steffan I, Zhuber K, Zweymuller K (2003) Four-year study of cobalt and chromium blood levels in patients managed with two different metal-on-metal total hip replacements. J Orthop Res 21:189–195CrossRefGoogle Scholar
  33. Li JP, Li SH, de Groot K, Layrolle P (2002) Macroporous biphasic calcium phosphate scaffold with high permeability/porosity ratio. Key Eng Mater 218:51–54CrossRefGoogle Scholar
  34. Li LC, Gao JC, Wang Y (2004) Evaluation of cyto-toxicity and corrosion behavior of alkali-heat-treated magnesium in simulated body fluid. Surf Coat Technol 185:92–98CrossRefGoogle Scholar
  35. Li JP, Li SH, van Blitterswijk CA, Groot K (2005) A novel porous Ti6A14 V: characterization and cell attachment. J Biomed Mater Res 73A:223–233CrossRefGoogle Scholar
  36. Li Z, Gu X, Lou S, Zheng Y (2008) The development of binary Mg-Ca alloys for use as biodegradable materials within bone. Biomaterials 29:1329–1344CrossRefGoogle Scholar
  37. Lin X, Tan L, Wang Q, Zhang G, Zhang B, Yang K (2013) In vivo degradation and tissue compatibility of ZK60 magnesium alloy with micro-arc oxidation coating in a transcortical model. Mater Sci Eng C33:3881–3888CrossRefGoogle Scholar
  38. Lin X, Yang X, Tan L, Li M, Wang X, Zhang Y, Yang K, Hu Z, Qiu J (2014) In vitro degradationand biocompatibility of a strontium-containing micro-arc oxidation coating on the biodegradable ZK60 magnesium alloy. Appl Surf Sci 288:718–726CrossRefGoogle Scholar
  39. Liu LJ, Schlesinger M (2009) Corrosion of magnesium and its alloys. Corros Sci 51:1733–1737CrossRefGoogle Scholar
  40. Liu C, Zhao Y, Chen Y, Liu P, Cai K (2014) Surface modification of magnesium alloy via cathodic plasma electrolysis and its influence on corrosion resistance and cytocompatibility. Mater Lett 132:15–18CrossRefGoogle Scholar
  41. Lopez M, Pereda M, Valle J, Lorenzo M, Alonso M, Escudero M (2010) Corrosion behavior of AZ31 magnesium alloy with different grain sizes in simulated biological fluids. Acta Biomater 6:1763–1771CrossRefGoogle Scholar
  42. Mabuchi M, Kubota K, Higashi K (1995) High strength and high strain rate super plasticity in a Mg-Mg2Si composite. Scr Metall Mater 33:331–335CrossRefGoogle Scholar
  43. Maguire M, Cowan J (2002) Magnesium chemistry and biochemistry. Biometals 15:203–210CrossRefGoogle Scholar
  44. Mao L, Yuana G, Niu J, Zong Y, Ding W (2013) In vitro degradation behavior and biocompatibility of Mg–Nd–Zn–Zr alloy byhydrofluoric acid treatment. Mater Sci Eng C33:242–250CrossRefGoogle Scholar
  45. Mueller WD, Nascimento ML, de Mele MFL (2010) Critical discussion of the results from different corrosion studies of Mg and Mg alloys for biomaterial applications. Acta Biomater 6:1749–1755CrossRefGoogle Scholar
  46. Murray GA, Semple JC (1981) Transfer of tensile loads from a prosthesis to bone using porous titanium. J Bone Joint Surg 63B:138–141CrossRefGoogle Scholar
  47. Nagels J, Stokdijk M, Rozing PM (2003) Stress shielding and bone resorption in shoulder arthroplasty. J Shoulder Elbow Surg 12:35–39CrossRefGoogle Scholar
  48. Ng WF, Chiu KY, Cheng FT (2010) Effect of ph on the in vitro corrosion rate of magnesium degradable implant material. Mater Sci Eng, C 30:898–903CrossRefGoogle Scholar
  49. Niinomi M, Nakai M, Hieda J (2012) Developement of new metallic alloys for biomedical applications. Acta Biomater 8:3888–3903CrossRefGoogle Scholar
  50. Orlov D, Ralston KD, Birbilis N, Estrin Y (2011) Enhanced corrosion resistance of Mg alloy ZK60 after processing by integrated extrusion and equal channel angular pressing. Acta Mater 59(15):6176–6186CrossRefGoogle Scholar
  51. Pamula E, Bacakova L et al (2008) The influence of pore size on colonization of poly(L-lactide-glycolide) scaffolds with human osteoblast-like MG 63 cells in vitro. J Mater Sci 19:425–435Google Scholar
  52. Pamula E, Filová E, Bacáková L, Lisá V, Adamczyk D (2009) Resorbable polymeric scaffolds for bone tissue engineering: the influence of their microstructure on the growth of human osteoblast-like MG 63 cells. J Biomed Mater Res A89:432–443CrossRefGoogle Scholar
  53. Pan YK, Chen CZ, Wang DG, Zhao TG (2013) Effects of phosphates on microstructure and bioactivity of micro-arc oxidized calcium phosphate coating on Mg-Zn-Zr magnesium alloy. Colloids Surf B 109:1–9CrossRefGoogle Scholar
  54. Persaud-Sharma D, McGoron A (2012) Biodegradable magnesium alloys: a review of material development and applications. J Biomater Tissue Eng 12:25–39CrossRefGoogle Scholar
  55. Pu Z, Outeiro JC, Batista AC et al (2011) Surface integrity in dry and cryogenic machining of AZ31b Mg alloy with varying cutting edge radius tools. Procedia Eng 19:282–287CrossRefGoogle Scholar
  56. Radha R, Sreekanth D (2017) Insight of magnesium alloys and composites for orthopedic implant applications—a review. J Magnes Alloys 5:286–312CrossRefGoogle Scholar
  57. Ralston KD, Birbilis N (2010) Effect of grain size on corrosion: a review. Corros Sci 66(7):075005CrossRefGoogle Scholar
  58. Raman RKS, Choudhary L (2013) Cracking of magnesium-based biodegradable implant alloys under the combined action of stress and corrosive body fluid: a review. Emerg Mater Res 2:219–228CrossRefGoogle Scholar
  59. Razavi M, Fathi MH, Meratian M (2010a) Fabrication and characterization of magnesium-fluorapatite nanocomposite for biomedical applications. Mater Charact 61:1363–1370CrossRefGoogle Scholar
  60. Razavi M, Fathi MH, Meratian M (2010b) Microstructure, mechanical properties and bio-corrosion evaluation of biodegradable AZ91-FA nanocomposites for biomedical applications. Mater Sci Eng, A 527:6938–6944CrossRefGoogle Scholar
  61. Razavi M, Fathi M, Savabi O, Razavi S, Hashemi B, Vashaee D, Tayebi L (2013) Surface modification of magnesium alloy implants by nanostructured bredigite coating. Mater Lett 113:174–178CrossRefGoogle Scholar
  62. Rojaee R, Fathi M, Raeissi K (2013) Controlling the degradation rate of AZ91 magnesium alloy via sol-gel thin films as derived nanostructured hydroxyapatite coating. Mater Sci Eng C33:3817–3825CrossRefGoogle Scholar
  63. Rosalbino F, De Negri S, Scavino G et al (2013) Microstructure and in vitro degradation performance of Mg-Zn-Mn alloys for biomedical application. J Biomed Mater Res A101:704–711CrossRefGoogle Scholar
  64. Seal CK, Vince K, Hodgson MA (2009) Biodegradable surgical implants based on magnesium alloys—a review of current research. Mater Sci Eng 4:1–5Google Scholar
  65. Sha BA (2003) Corrosion resistance of magnesium alloys. ASM Handbook 13A, OH, USAGoogle Scholar
  66. Sharma DP, McGoron A, Biomim J (2012) Biodegradable magnesium alloys: a review of material development and applications. Biomater Tissue Eng 12:25–39CrossRefGoogle Scholar
  67. Song G (2007) Control of biodegradation of biocompatible magnesium alloys. Corros Sci 49(4):1696–1701CrossRefGoogle Scholar
  68. Song GL, Atrens A (1999) Corrosion mechanisms of magnesium alloys. Adv Eng Mater 1:11–33CrossRefGoogle Scholar
  69. Song G, Song S (2007) A possible biodegradable magnesium implant material. Adv Eng Mater 9:298–302CrossRefGoogle Scholar
  70. Staiger MP, Pietaka AM, Huadmai J, Diasb G (2006) Magnesium and its alloys as orthopedic biomaterials: a review. Biomaterials 27:1728–1734CrossRefGoogle Scholar
  71. Tang YC, Katsuma S, Fujimoto S, Hiromoto S (2006) Electrochemical study of Type 304 and 316L stainless steels in simulated body fluids and cell cultures. Acta Biomater 2:709–715CrossRefGoogle Scholar
  72. Tomozawa M, Hiromoto S (2011) Growth mechanism of hydroxyapatite coatings formed on pure magnesium and corrosion behavior of the coated magnesium. Appl Surf Sci 257(19):8253–8257CrossRefGoogle Scholar
  73. Wagener V, Faltz AS, Killian MS, Schmuki P, Virtanen S (2015) Protein interactions with corroding metal surfaces: comparison of Mg and Fe. Faraday Discuss 180:347–360CrossRefGoogle Scholar
  74. Wan P, Tan L, Yang K (2016) Biodegradable materials for bone repairs: a review. J Mater Sci Technol 32:827–834CrossRefGoogle Scholar
  75. Wang H, Shi Z (2011) In vitro biodegradation behavior of magnesium and magnesium alloy. J Biomed Mater Res, Part B 98:203–209CrossRefGoogle Scholar
  76. Wang HX, Guan SK, Wang X, Ren CX, Wang LG (2010) In vitro degradation and mechanical integrity of Mg-Zn-Ca alloy coated with Ca-deficient hydroxyapatite by the pulse electrodeposition process. Acta Biomater 6:1743–1748CrossRefGoogle Scholar
  77. Wang H, Guan S, Wang Y, Liu H, Wang L, Ren C, Zhu S, Chen K (2011) In vivo degradation behavior of Ca-deficient hydroxyapatite coated Mg-Zn-Ca alloy for bone implant application. Colloids Surf B 88:254–259CrossRefGoogle Scholar
  78. Wang J, Tang J, Zhang P, Li Y, Wang J, Lai Y (2012) Acceleration effect of basic fibroblast growth factor on the regeneration of peripheral nerve through a 15-mm gap. J Biomed Mater Res B100:1691–1701CrossRefGoogle Scholar
  79. Wang X, Xu S, Zhou S, Xu W, Leary M, Choong P, Qian M, Brandt M, Xie Y (2016) Topological design and additive manufacturing of porous metals for bone scaffolds and orthopaedic implants: a review. Biomaterials 83:127–141CrossRefGoogle Scholar
  80. Wang G, Fu H, Zhao Y, Zhou K, Zhu S (2017) Aging microstructural characteristics of ZA-27 alloy and SiCdZA-27 composite. Trans Nonferrous Met Soc China 27:2007–2014CrossRefGoogle Scholar
  81. Willumeit-Römer R, Wendel HP, Mihailova B, Agha NA, Feyerabend F (2014) Magnesium degradation influenced by buffering salts in concentrations typical of in vitro and in vivo models. Eur Cells Mater 28:29Google Scholar
  82. Witte F (2010) The history of biodegradable magnesium implants: a review. Acta Biomater 6:1680–1692CrossRefGoogle Scholar
  83. Witte F, Kaese V, Haferkamp H, Switzer E, Wirth C, Windhagen H (2005) In vivo corrosion of four magnesium alloys and the associated bone response. Biomaterials 26:3557–3563CrossRefGoogle Scholar
  84. Witte F, Fischer J, Nellesen J, Crostack H, Kaese V, Pisch A, Windhagen H (2006) In vitro and in vivo corrosion measurements of magnesium alloys. Biomaterials 27:1013–1018CrossRefGoogle Scholar
  85. Witte F, Feyerabend F, Maier P, Fischer J, Stormer M, Blawert C, Dietzel W, Hort N (2007) Biodegradable magnesium-hydroxyapatite metal matrix composites. Biomaterials 28:2163–2174CrossRefGoogle Scholar
  86. Witte F, Hort N, Vogt C, Kainer K, Willumeit R, Feyeraben F (2008) Degradable biomaterials based on magnesium corrosion. Curr Opin Solid State Mater Sci 12:63–72CrossRefGoogle Scholar
  87. Wong HM, Yeung KW, Lam KO, Tam V, Chu PK, Luk KD, Cheung K (2010) A biodegradable polymer-based coating to control the performance of magnesium alloy orthopaedic implants. Biomaterials 31:2084–2096CrossRefGoogle Scholar
  88. Wu G, Ibrahim JM, Chu PK (2013) Corrosion behavior of Nd ion implanted Mg-Gd-Zn-Zr alloy in simulated body fluid. Surf Coat Technol 233:2–12CrossRefGoogle Scholar
  89. Yamamoto A, Hiromoto S (2009) Effect of inorganic salts, amino acids and proteins on the degradation of pure magnesium in vitro. Mater Sci and Eng C 29:1559–1568CrossRefGoogle Scholar
  90. Yang J, Cui F, Lee IS (2011) Surface modifications of magnesium alloys for biomedical applications. Ann Biomed Eng 39:1857–1871CrossRefGoogle Scholar
  91. Zardiackas LD, Dillon LD, Mitchell DW, Nunnery LA, Poggie R (2001) Structure, metallurgy and mechanical properties of porous tantalum foam. J Biomed Mater Res 58:180–187CrossRefGoogle Scholar
  92. Zhang LN, Hou ZT, Ye X, Xu ZB, Bai XL, Shang P (2013) Aligned single-crystalline perovskite microwave arrays for high-performance flexible image sensors with long-term stability. Front Mater Sci 7(3):227–236CrossRefGoogle Scholar
  93. Zhuang H, Han Y, Feng A (2008) Preparation, mechanical properties and in vitro biodegradation of porous magnesium scaffolds. Mater Sci Eng C28:1462–1466CrossRefGoogle Scholar
  94. Živić F, Grujović N, Manivasagam G, Richard C, Landoulsi J, Petrović V (2014) The potential of magnesium alloys as bioabsorbable/biodegradable implants for biomedical applications. Tribol Ind 36:67–73Google Scholar
  95. Zomorodian A, Brusciotti F et al (2012) Corrosion resistance of a composite polymeric coating applied on biodegradable AZ31 magnesium alloy. Surf Coat Technol 206:4368–4375CrossRefGoogle Scholar
  96. Zomorodian A, Garcia M, Fernandes J, Fernandes M, Montemor M (2013) Corrosion resistance of a composite polymeric coating applied on biodegradableAZ31 magnesium alloy. Acta Biomater 9:8660–8670CrossRefGoogle Scholar
  97. Zou X, Li H, Bünger M, Egund N, Lind M, Bünger C (2004) Bone ingrowth characteristics of porous tantalum and carbon fiber interbody devices: an experimental study in pigs. Spine J 4:99–105CrossRefGoogle Scholar
  98. Zreiqat H, Howlett C, Zannettion A, Evans P, Knabe C, Shakibaei M (2002) Mechanisms of magnesium-stimulated adhesion of osteoblastic cells to commonly used orthopaedic implants. Biomed Mater Res 62:175–184CrossRefGoogle Scholar

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© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Technische Universität BerlinBerlinGermany
  2. 2.Department of Materials EngineeringInstitute of Technology BerlinBerlinGermany

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