Biodegradable magnesium alloys as temporary orthopaedic implants: a review
- 327 Downloads
The study of innovative biodegradable implant materials is one of the most interesting research topics at the forefront in the area of biomaterials. Biodegradable implant materials in the human body can be gradually dissolved, absorbed, consumed or excreted, so there is no need for the secondary surgery to remove implants after the surgery regions have healed. However, most of the biodegradable materials, usually polymers, do not have good mechanical properties to be reliable for bearing the load of the body. Magnesium and its alloys due to the excellent biodegradability and biocompatibility as well as the suitable mechanical compatibility with human bone are very promising candidates for the development of temporary, degradable implants in load-bearing applications. However, Mg alloys are corrosion susceptible in a biological environment. Besides, the high corrosion rate and the low bioactivity of magnesium implants are the challenging problems, which need to be resolved before employing them in clinical applications. This paper provides a review of state-of-the-art of magnesium alloy implants for orthopedic and tissue engineering applications and describes recent progress in the design of novel structure design Mg alloys and potential approaches to improve their biodegradation performance.
KeywordsMagnesium Biomaterial Biodegradable Temporary implant
The authors would like to thank Department of Materials Engineering, Institute of Technology Berlin for the extremely helpful guidance in carrying out the review paper and providing them with the appropriate data required.
- Davies JR (2003) Metallic materials in handbook of materials for medical devices. ASM International, Materials Park, pp 21–50Google Scholar
- Frost HM (1989) The biology of fracture healing. An overview for clinicians. Part I. Clin Orthop Relat Res 248:283–293Google Scholar
- González S et al. (2013) Biodegradation and mechanical integrity of magnesium and magnesium alloys suitable for implants, Chapter 12Google Scholar
- Jacobs JJ, Hallab NJ, Skipor AK, Urban RM (2003) Metal degradation products: a cause for concern in metal-metal bearings? Clin Orthop Relat Res 417:139–147Google Scholar
- Pamula E, Bacakova L et al (2008) The influence of pore size on colonization of poly(L-lactide-glycolide) scaffolds with human osteoblast-like MG 63 cells in vitro. J Mater Sci 19:425–435Google Scholar
- Seal CK, Vince K, Hodgson MA (2009) Biodegradable surgical implants based on magnesium alloys—a review of current research. Mater Sci Eng 4:1–5Google Scholar
- Sha BA (2003) Corrosion resistance of magnesium alloys. ASM Handbook 13A, OH, USAGoogle Scholar
- Willumeit-Römer R, Wendel HP, Mihailova B, Agha NA, Feyerabend F (2014) Magnesium degradation influenced by buffering salts in concentrations typical of in vitro and in vivo models. Eur Cells Mater 28:29Google Scholar
- Živić F, Grujović N, Manivasagam G, Richard C, Landoulsi J, Petrović V (2014) The potential of magnesium alloys as bioabsorbable/biodegradable implants for biomedical applications. Tribol Ind 36:67–73Google Scholar