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BioMetals

pp 1–9 | Cite as

Selenium-Rich Yeast protects against aluminum-induced peroxidation of lipide and inflammation in mice liver

  • Junchong Luo
  • Xiaowen Li
  • Xinran Li
  • Yongming He
  • Mengdan Zhang
  • Changyu Cao
  • Kai Wang
Article
  • 35 Downloads

Abstract

To investigate the effect of Selenium Rich Yeast (SeY) on hepatotoxicity of Aluminium (Al), SeY (0.1 mg/kg) was orally administrated to aluminium-exposed mice (10 mg/kg) for 28 days. The risk of oxidative stress was assessed by detecting the total antioxidant capacity (T-AOC), catalase activity, H2O2 content, and mRNA levels of the Keap1/Nrf-2/HO-1 pathway. Inflammatory reactions were assessed by detecting the mRNA levels of inflammatory biomarkers. Our results showed that SeY protected against the liver histological changes induce by Al. The body weight gain of mice treated with SeY + Al restore to normal compare with mice exposed to Al alone. Al treatment significantly decreased the activities of antioxidant enzymes, reduced T-AOC levels, and up-regulated the mRNA level of Nrf2 and HO-1, thereby ultimately leading to peroxidation. SeY shown a significant protective effect against oxidative stress caused by Al. In addition, Al exposure induced inflammatory responses in rat liver by promoting the release of inflammatory cytokines (TNF-a, NF-kB, TNF-R1, IL-1, IL-6, and COX-2). SeY protected against changes in liver by regulating the mRNA expression levels of inflammatory factors. These results suggested that Se protected the liver from the Al-induced hepatotoxicity by regulating the mRNA level of Keap1/Nrf2/HO-1, and inhibited inflammatory responses by down-regulating the expression level of inflammatory cytokine.

Keywords

Selenium-Rich Yeast (SeYAluminum Inflammation Oxidative stress Mice liver 

Notes

Acknowledgements

This work was supported by Foshan University research star-up project (099/gg07037) and Key Laboratory of preventive veterinary medicine in Guangdong Provincial Department of Education (2014KTSPT037).

Compliance with ethical standards

Conflict of interest

The authors declare that there are no conflicts of interest.

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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.College of Science and EngineeringFoshan UniversityFoshanPeople’s Republic of China

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