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Biotechnology Letters

, Volume 41, Issue 12, pp 1451–1458 | Cite as

Recombinant human Cyclophilin A stimulates hair follicle cells via Wnt/β-catenin signaling pathway

  • Kiyoon Kim
  • Wonchae ChoeEmail author
Original Research Paper
  • 94 Downloads

Abstract

Objectives

To explore potential effects of recombinant peptidyl-prolyl isomerase human Cyclophilin A (CypA) in the growth of mouse hair and human hair follicle dermal papilla cells (HDP).

Results

The hair growth of 8-weeks C57BL/6 mouse was significantly stimulated by recombinant human CypA protein. CypA also promoted Human Dermal Papilla (HDP) cell growth and induced β-catenin protein through GSK3β inhibition.

Conclusions

The molecular chaperone CypA stimulates hair follicle and HDP cells through Wnt/β-catenin signaling pathway, suggesting that it might be a key molecule for hair loss disorder therapy.

Keywords

Cyclophilin A Hair growth Human hair follicle dermal papilla cells β-catenin 

Notes

Acknowledgements

This work was funded by a National Research Foundation of Korea (NRF) Grants funded by Korean government (MEST) (NRF-2017R1A2B2002289, NRF-2016R1A6A3A11930398, NRF-2018R1A6A1A03025124).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular Biology, School of MedicineKyung Hee UniversitySeoulRepublic of Korea
  2. 2.Department of Biomedical Science, Graduate SchoolKyung Hee UniversitySeoulRepublic of Korea
  3. 3.Department of Biochemistry and Molecular Biology, Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, School of MedicineKyung Hee UniversitySeoulRepublic of Korea

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