Recombinant human Cyclophilin A stimulates hair follicle cells via Wnt/β-catenin signaling pathway
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To explore potential effects of recombinant peptidyl-prolyl isomerase human Cyclophilin A (CypA) in the growth of mouse hair and human hair follicle dermal papilla cells (HDP).
The hair growth of 8-weeks C57BL/6 mouse was significantly stimulated by recombinant human CypA protein. CypA also promoted Human Dermal Papilla (HDP) cell growth and induced β-catenin protein through GSK3β inhibition.
The molecular chaperone CypA stimulates hair follicle and HDP cells through Wnt/β-catenin signaling pathway, suggesting that it might be a key molecule for hair loss disorder therapy.
KeywordsCyclophilin A Hair growth Human hair follicle dermal papilla cells β-catenin
This work was funded by a National Research Foundation of Korea (NRF) Grants funded by Korean government (MEST) (NRF-2017R1A2B2002289, NRF-2016R1A6A3A11930398, NRF-2018R1A6A1A03025124).
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Conflict of interest
The authors declare that they have no conflict of interest.