Advances in heterologous biosynthesis of plant and fungal natural products by modular co-culture engineering
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Heterologous biosynthesis has been long pursued as a viable approach for high efficiency production of natural products with various industrial values. Conventional methods for heterologous biosynthesis use the mono-culture of an engineered microbe for accommodating the whole target biosynthetic pathway to produce the desired product. The emergence of modular co-culture engineering, which divides the pathway between multiple co-culture strains, presents a new perspective to conduct heterologous biosynthesis and improve the bioproduction performance of natural products. This review highlights recent advances in utilizing the modular co-culture engineering approaches to address the challenges of plant and fungal natural product biosynthesis. Potential directions for future research in this promising field are also discussed.
KeywordsBioproduction improvement Heterologous biosynthesis Modular co-culture engineering Natural product Plants and fungus
This work is supported by startup research funds provided by Rutgers, The State University of New Jersey. Tingting Chen is a recipient of CSC PhD fellowship.
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