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Biochemical Genetics

, Volume 57, Issue 6, pp 813–826 | Cite as

NEMP1 Promotes Tamoxifen Resistance in Breast Cancer Cells

  • Yanyan Liu
  • Chuang Tong
  • Jun Cao
  • Maoming XiongEmail author
Original Article

Abstract

Breast cancer (BC) is a worldwide malignant and a leading death cancer in women. Studies have shown that adjuvant tamoxifen reduces the recurrence rate and metastasis in BC. Even though tamoxifen has been used for the therapy of BC for decades, the resistance of it on BC cells could not be ignored. In this study, we first established a tamoxifen-resistant BC cell line and then demonstrated the overexpression of nuclear envelope integral membrane protein 1 (NEMP1) in the tamoxifen-resistant BC cells. Moreover, through a cell viability assay combined with depletion or overexpression technology, we addressed the important role of NEMP1 for the tamoxifen resistance in BC cells. Importantly, we further revealed that NEMP1 modulated tamoxifen resistance by regulating nuclear receptor coactivator 1 (NCOA1). In general, NEMP1 shows responsibility for the resistance of tamoxifen through regulating NCOA1 in BC cells. These results broaden the understanding of the tamoxifen resistance during the chemotherapy in BC and may provide new therapy method for BC.

Keywords

Breast cancer NEMP1 NCOA1 Cell viability Tamoxifen resistance 

Notes

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Human and Animal Rights

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Yanyan Liu
    • 1
    • 2
  • Chuang Tong
    • 2
  • Jun Cao
    • 2
  • Maoming Xiong
    • 1
    Email author
  1. 1.Department of General SurgeryThe First Affiliated Hospital of Anhui Medical UniversityHefeiChina
  2. 2.Department of General SurgeryThe Third Affiliated Hospital of Anhui Medical UniversityHefeiChina

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