Investigation of Hemocompatibility of Rotary Blood Pumps: The Case of the Sputnik Ventricular Assist Device

  • M. V. DenisovEmail author
  • D. V. Telyshev
  • S. V. Selishchev
  • A. N. Romanova

The hemocompatibility of Sputnik rotary blood pumps of the first and second generation (Sputnik-1 and Sputnik-2) was studied using numerical simulation. The influence of the flow geometry on scalar shear stresses (SSS), the residence time, and the volume of recirculation zones was determined. Volume fractions of SSS were obtained for the threshold stress levels of 9, 50, and 150 Pa at a fixed pump speed of 8000 rpm (mean flow rate, 4.5 L/min; pressure, 80 mm Hg). At all selected threshold stress levels, the elevated SSS volumes for the first-generation rotor pump were found to exceed those for the second-generation pump. Thus, the latter has a lesser effect on blood cells. The average residence time was found to be 39 and 29 ms for the Sputnik-1 and Sputnik-2 pumps, respectively; the respective recirculation zone volumes were 4.36 and 1.72 mL. The lesser volume of recirculation zones for the second-generation rotor pump reduces the probability of formation of stagnation zones and, therefore, the probability of clotting. The simulation results showed that upgrading the design of the Sputnik rotor pump had a positive effect on its hemocompatibility.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Mendis, Sh., Puska, P., and Norrving, B., Global Atlas on h Organization, World Heart Federation, World Stroke Organization (2011).Google Scholar
  2. 2.
    Miller, L. W., Guglin, M., and Rogers, J., “Cost of ventricular assist devices: Can we afford the progress?” Circulation, 127, No. 6, 743-748 (2013).CrossRefGoogle Scholar
  3. 3.
    Mulloy, D. P., Bhamidipati, C. M., Stone, M. L., Ailawadi, G., Kron, I. L., and Kern, J. A., “Orthotopic heart transplant versus left ventricular assist device: A national comparison of cost and survival,” J. Thor. Cardiovasc. Surg., 145, No. 2, 566-574 (2013).CrossRefGoogle Scholar
  4. 4.
    Petukhov, D. S., Selishchev, S. V., and Telyshev, D. V., “Development of left ventricular assist devices as the most effective acute heart failure therapy,” Biomed. Eng., 48, No. 6, 328-330 (2015).CrossRefGoogle Scholar
  5. 5.
    Selishchev, S. V. and Telyshev, D. V., “Optimisation of the Sputnik-VAD design,” Int. J. Artif. Org., 39, No. 8, 407-414 (2016).CrossRefGoogle Scholar
  6. 6.
    Telyshev, D. V., Denisov, M. V., and Selishchev, S. V., “The effect of rotor geometry on the H−Q curves of the Sputnik implantable pediatric rotary blood pump,” Biomed. Eng., 50, No. 6, 420-424 (2017).CrossRefGoogle Scholar
  7. 7.
    Denisov, M. V., Selishchev, S. V., Telyshev, D. V., and Frolova, E. A., “Development of medical and technical requirements and simulation of the flow–pressure characteristics of the Sputnik pediatric rotary blood pump,” Biomed. Eng., 50, No. 5, 296-299 (2017).CrossRefGoogle Scholar
  8. 8.
    Telyshev, D. V., Denisov, M. V., Pugovkin, A., Selishchev, S. V., and Nesterenko, I. V., “The progress in the novel pediatric rotary blood pump Sputnik development,” Artif. Organs, 42, No. 4, 432-443 (2018).CrossRefGoogle Scholar
  9. 9.
    Lopes, G. Jr., Bock, E., and Gomez, L., “Numerical analyses for low Reynolds flow in a ventricular assist device low Reynolds flow in a ventricular assist device,” Artif. Org., 41, No. 6, 30-40 (2017).CrossRefGoogle Scholar
  10. 10.
    Sohrabi, S. and Liu, Y., “A cellular model of shear-induced hemolysis,” Artif. Org., 41, No. 9, 1-12 (2017).CrossRefGoogle Scholar
  11. 11.
    Versteeg, H. K. and Malalasekera, W., An Introduction to Computational Fluid Dynamics: The Finite Volume Method, Harlow, Pearson Education Limited (2007).Google Scholar
  12. 12.
    Bludszuweit, C., “Three-dimensional numerical prediction of stress loading of blood particles in a centrifugal pump,” Artif. Org., 19, No. 7, 590-596 (1995).CrossRefGoogle Scholar
  13. 13.
    Science Clarified: Blood, AdvaMeg (2007), pp. 50-56.Google Scholar
  14. 14.
    Giersiepen, M., Wurzinger, L. J., Opitz, R., and Reul, H., “Estimation of shear stress-related blood damage in heart valve prosthesis − in vitro comparison of 25 aortic valves,” Int. J. Artif. Org., 13, 300-306 (1990).CrossRefGoogle Scholar
  15. 15.
    Hochareon, P., Manning, K. B., Fontaine, A. A., Tarbell, J. M., and Deutsch, S., “Correlation of in vivo clot deposition with the flow characteristics in the 50 cc Penn State artificial heart: A preliminary study,” ASAIO J., 50, No. 6, 537-542 (2004).CrossRefGoogle Scholar
  16. 16.
    Fraser, K. H., Zhang, T., Taskin, M. E., Griffith, B. P., and Wu, Z. J., “Computational fluid dynamics analysis of thrombosis potential in ventricular assist device drainage cannulae,” ASAIO J., 56, No. 3, 157-163 (2010).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • M. V. Denisov
    • 1
    Email author
  • D. V. Telyshev
    • 1
    • 2
  • S. V. Selishchev
    • 1
  • A. N. Romanova
    • 1
  1. 1.Institute of Biomedical SystemsNational Research University of Electronic Technology (MIET)MoscowRussia
  2. 2.Institute for Bionic Technologies and EngineeringI. M. Sechenov First Moscow State Medical University, Russian Ministry of HealthMoscowRussia

Personalised recommendations