, Volume 20, Issue 6, pp 763–782 | Cite as

d-Galactose-induced accelerated aging model: an overview

  • Khairunnuur Fairuz AzmanEmail author
  • Rahimah Zakaria
Review Article


To facilitate the process of aging healthily and prevent age-related health problems, efforts to properly understand aging mechanisms and develop effective and affordable anti-aging interventions are deemed necessary. Systemic administration of d-galactose has been established to artificially induce senescence in vitro and in vivo as well as for anti-aging therapeutic interventions studies. The aim of this article is to comprehensively discuss the use of d-galactose to generate a model of accelerated aging and its possible underlying mechanisms involved in different tissues/organs.


d-Galactose Aging model Senescence Anti-aging 



The authors would like to acknowledge School of Medical Sciences, Universiti Sains Malaysia and short-term research grant of Universiti Sains Malaysia (304/PPSP/6315093).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.


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© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of Physiology, School of Medical SciencesUniversiti Sains MalaysiaKota BharuMalaysia

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