Bulletin of Experimental Biology and Medicine

, Volume 168, Issue 1, pp 10–13 | Cite as

Heparin Modulates the Main Properties of the Central Nervous System in Experimental Post-Traumatic Stress Disorder: A New Concept of the Mechanisms of Pathogenesis and Treatment

  • M. V. KondashevskayaEmail author

Elevated plus-maze test was used to reveal the role of excitation and inhibition mechanisms in the CNS in the organization of the behavior of male Wistar rats under normal conditions and during modeling experimental post-traumatic stress disorder (with or without administration of low doses of high-molecular-weight heparin). The data about insufficiency in the system of excitation mechanisms and pronounced excess in the system of inhibition mechanisms in post-traumatic stress disorder are prioritized. Heparin seems to be a promising and effective preparation to cope with extreme psychotraumatic abnormalities in CNS.

Key Words

post-traumatic stress disorder elevated plus-maze behavior heparin rat 


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Research Institute of Human MorphologyMoscowRussia

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