Bulletin of Experimental Biology and Medicine

, Volume 167, Issue 6, pp 791–794 | Cite as

Peculiarities of RIG-1 Expression in Placental Villi in Preeclampsia

  • N. V. Nizyaeva
  • N. A. Lomova
  • E. Yu. Amiraslanov
  • N. E. Kan
  • M. N. Nagovitsyna
  • A. I. ShchegolevEmail author

The expression of RIG-1 in placenta samples was assessed in women of reproductive age with early- and late-onset preeclampsia and cesarean delivery at 27-39 weeks of gestation. The highest expression of RIG-1 was found in the syncytiotrophoblast of placental villi in the group with uncomplicated full-term pregnancy (normal); RIG-1 expression in groups with early- and late-onset preeclampsia was significantly (p<0.01) lower. In decidual cells, RIG-1 expression was also maximum in normal pregnancy and significantly (p<0.01) lower in lateonset preeclampsia. In the endothelium of villous capillaries, the maximum expression was observed in normal full-term pregnancy and in late-onset preeclampsia, while in early-onset preeclampsia this parameter was significantly (p<0.01) lower. It can be assumed that different variants of preeclampsia are mediated by similar pathogenetic mechanisms, including those related to immature molecular profile of the trophoblast and decidual cells, probably due to impaired stem cell activity in the placenta determining higher vulnerability and reduced regeneration capacity of the placental tissue. This is due to the fact that RIG-1 is one of the important signaling molecules that promote activation of stem cell and tissue regeneration.

Key Words

decidual cells placenta preeclampsia RIG-1 trophoblast 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • N. V. Nizyaeva
    • 1
  • N. A. Lomova
    • 1
  • E. Yu. Amiraslanov
    • 1
  • N. E. Kan
    • 1
  • M. N. Nagovitsyna
    • 1
  • A. I. Shchegolev
    • 1
    Email author
  1. 1.V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and PerinatologyMinistry of Health of the Russian FederationMoscowRussia

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