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Bulletin of Experimental Biology and Medicine

, Volume 167, Issue 6, pp 763–766 | Cite as

Antimicrobial Effect of Albumin on Bacteria and Yeast Cells

  • V. G. ArzumanyanEmail author
  • I. M. Ozhovan
  • O. A. Svitich
Article

We studied the effect of albumin (human serum, bovine serum, and ovalbumin) on Candida albicans, Cryptococcus neoformans, E. coli, and Staphylococcus aureus cells. Antimicrobial activity was evaluated by microscopy, inoculation, and spectrophotometry. All three albumins showed antimicrobial activity against all studied cultures and their effect was dose-dependent. At concentrations of serum albumins close to physiological (50 mg/ml), the cells of microorganisms were destroyed with the formation of debris vesicles, while at lower concentrations (10 mg/ml), only cell membrane integrity was impaired. According to spectrophotometry, activity of the human serum albumin in a physiological concentration against the studied microorganisms was close to the activity of native human serum.

Key Words

albumin antimicrobial action bacteria yeast serum 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • V. G. Arzumanyan
    • 1
    Email author
  • I. M. Ozhovan
    • 1
  • O. A. Svitich
    • 1
  1. 1.I. I. Mechnikov Research Institute of Vaccines and SerumsMoscowRussia

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