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Bulletin of Experimental Biology and Medicine

, Volume 167, Issue 6, pp 744–746 | Cite as

Membranotropic and Antiradical Properties of 2-Nitroxysuccinate 3-Hydroxy-6-Methyl-2-Ethylpyridine

  • D. A. PoletaevaEmail author
  • I. I. Faingold
  • Yu. V. Soldatova
  • A. V. Smolina
  • B. S. Fedorov
  • A. B. Eremeev
  • R. A. Kotelnikova
Article
  • 5 Downloads

We studied membranotropic properties of NO donor 2-nitroxysuccinate 3-hydroxy-6-methyl-2-ethylpyridine and its structural analog succinate 3-hydroxy-6-methyl-2-ethylpyridine (Mexidol). It was shown that the compounds under study are incorporated into modeled membranes and form long-living complexes with pyrene in the region of fatty acid tails of phospholipids. Luminol-amplified chemiluminescence analysis showed that both compounds exhibited antiradical activity and in a concentration of 0.1 mM reduced chemiluminescence intensity by more than 70%. 2-Nitroxysuccinate 3-hydroxy-6-methyl-2-ethylpyridine inhibited catalytic activity of monoamine oxidase A more efficiently than its structural analogue Mexidol.

Key Words

membranotropic activity antioxidants free radicals monoamine oxidase cardiovascular disease 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • D. A. Poletaeva
    • 1
    Email author
  • I. I. Faingold
    • 1
    • 2
  • Yu. V. Soldatova
    • 1
    • 2
  • A. V. Smolina
    • 1
  • B. S. Fedorov
    • 1
  • A. B. Eremeev
    • 1
  • R. A. Kotelnikova
    • 1
  1. 1.Institute of Problems of Chemical PhysicsRussian Academy of SciencesChernogolovkaRussia
  2. 2.Scientific Educational CenterMoscow Regional State UniversityChernogolovkaRussia

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