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Bulletin of Experimental Biology and Medicine

, Volume 167, Issue 5, pp 706–710 | Cite as

A Translational Model of Chronic Heart Failure

  • S. A. KryzhanovskiiEmail author
  • I. B. Tsorin
  • V. N. Stolyaruk
  • M. B. Vititnova
  • E. O. Ionova
  • V. V. Barchukov
  • I. A. Miroshkina
  • A. V. Sorokina
  • L. M. Kozhevnikova
  • A. D. Durnev
Article
  • 15 Downloads

We created a translational model of chronic heart failure in rats that developed in 3 months after reproducing experimental anterior transmural myocardial infarction. The model simulated the basic clinicodiagnostic criteria of this disease: impaired contractility and dilatation of heart ventricles, signs of venous congestion, elevated plasma content of biochemical markers, and abnormal overexpression of AT1aR and β-adrenoceptors.

Key Words

translational model chronic heart failure echocardiography receptor expression rat 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • S. A. Kryzhanovskii
    • 1
    Email author
  • I. B. Tsorin
    • 1
  • V. N. Stolyaruk
    • 1
  • M. B. Vititnova
    • 1
  • E. O. Ionova
    • 1
  • V. V. Barchukov
    • 1
  • I. A. Miroshkina
    • 1
  • A. V. Sorokina
    • 1
  • L. M. Kozhevnikova
    • 1
  • A. D. Durnev
    • 1
  1. 1.V. V. Zakusov Research Institute of PharmacologyMoscowRussia

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