Bulletin of Experimental Biology and Medicine

, Volume 167, Issue 5, pp 694–697 | Cite as

Reaction of Mast Cells in the Zone of Polypropylene Mesh Implantation

  • A. A. GrigoryukEmail author
  • S. A. Belov
  • A. E. Kotsyuba

Reaction of mast cells of adult male Wistar rats (n=15) in the zone of polypropylene mesh fixation was studied by histochemical, immunohistochemical, and traditional morphological methods on days 1, 5, 10, and 30 after implantation. Immediately after the intervention, mast cells stimulated the processes aimed at wound healing. Secretion of mast cells was clearly regulatory. These cells migrated to the zone of injury for subsequent activation of their function. The number of cNOS+ mast cells near the polypropylene mesh was maximum on day 1 and the number of iNOS+ mast cells peaked on day 5 of the experiment, which probably represented a compensatory reaction. Presumably, stimulation of fibrillogenesis was largely due to the activatory effect of mast cells on the fibroblast function, but not to collagen production by these mast cells.

Key Words

mast cells polypropylene mesh experiment 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • A. A. Grigoryuk
    • 1
    Email author
  • S. A. Belov
    • 2
  • A. E. Kotsyuba
    • 1
  1. 1.Pacific State Medical UniversityVladivostokRussia
  2. 2.Primorye Territorial Tuberculosis Control CenterVladivostokRussia

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