Bulletin of Experimental Biology and Medicine

, Volume 167, Issue 5, pp 641–644 | Cite as

Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats

  • L. G. KolikEmail author
  • A. V. Nadorova
  • T. A. Antipova
  • S. V. Kruglov
  • V. S. Kudrin
  • A. D. Durnev

The effects of a peptide anxiolytic Selank synthesized on the basis of the endogenous peptide tuftsin on memory impairment and content of brain-derived neurotrophic factor (BDNF) in brain structures were analyzed in outbred rats receiving 10% ethanol as the only source of fluid for 30 weeks. In the object recognition test, Selank (0.3 mg/kg a day, 7 days, intraperitoneally) produced a cognitive-stimulating effect in 9 months rats not exposed to ethanol (p<0.05) and prevented the formation of ethanol-induced memory and attention disturbances (p<0.01) developing during alcohol withdrawal. In ex vivo experiments, Selank prevented ethanol-induced increase in BDNF content in the hippocampus and frontal cortex (p<0.05). These results indicate positive effects of the tuftsin analogue on age-related memory disturbances associated with chronic alcohol intoxication and confirm the involvement of the neurotrophin mechanism related to BDNF production into the effect of Selank.

Key Words

Selank alcohol cognitive functions BDNF rats 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Inozemtseva LS, Karpenko EA, Dolotov OV, Levitskaya NG, Andreeva LA, Grivennikov IA, Kamensky AA. Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo. Dokl. Biol. Sci. 2008;421(1):241-243.CrossRefGoogle Scholar
  2. 2.
    Kolik LG, Nadorova AV, Kozlovskaya MM. Efficacy of peptide anxiolytic Selank during modeling of withdrawal syndrome in rats with stable alcoholic motivation. Bull. Exp. Biol. Med. 2014;157(1):52-55.CrossRefGoogle Scholar
  3. 3.
    Teleshova ES, Bochkarev VK, Syunyakov TS, Bugaeva TP, Neznamov GG. Results of clinical and pharmacological studies of peptide anxiolitik Selank. Psikhiatriya. 2010;(4):26-35. Russian.Google Scholar
  4. 4.
    Ebada ME, Latif LM, Kendall DA, Pardon MC. Corticosterone protects against memory impairments and reduced hippocampal BDNF levels induced by a chronic low dose of ethanol in C57BL/6J mice. Rom. J. Morphol. Embryol. 2014;55(4):1303-1316.PubMedGoogle Scholar
  5. 5.
    Hansen AW, Almeida FB, Bandiera S, Pulcinelli RR, Fragoso ALR, Schneider R Jr, Barros HMT, Gomez R. Taurine restores the exploratory behavior following alcohol withdrawal and decreases BDNF mRNA expression in the frontal cortex of chronic alcohol-treated rats. Pharmacol. Biochem. Behav. 2017;161(10):6-12.CrossRefGoogle Scholar
  6. 6.
    Kurien BT, Scofield RH. Western blotting: an introduction. Methods Mol. Biol. 2015;1312:17-30.CrossRefGoogle Scholar
  7. 7.
    Kuźma E, Llewellyn DJ, Langa KM, Wallace RB, Lang IA. History of alcohol use disorders and risk of severe cognitive impairment: a 19-year prospective cohort study. Am. J. Geriatr. Psychiatry. 2014;22(10):1047-1054.CrossRefGoogle Scholar
  8. 8.
    Le Berre AP, Fama R, Sullivan EV. Executive functions, memory, and social Cognitive deficits and recovery in chronic alcoholism: a critical review to inform future research. Alcohol. Clin. Exp. Res. 2017;41(8):1432-1443.CrossRefGoogle Scholar
  9. 9.
    Ritchie K, Villebrun D. Epidemiology of alcohol-related dementia. Handb. Clin. Neurol. 2008;89:845-850.CrossRefGoogle Scholar
  10. 10.
    Schunck RV, Torres IL, Laste G, de Souza A, Macedo IC, Valle MT, Salomón JL, Moreira S, Kuo J, Arbo MD, Dallegrave E, Leal MB. Protracted alcohol abstinence induces analgesia in rats: possible relationships with BDNF and interleukin-10. Pharmacol. Biochem. Behav. 2015;135:64-69.CrossRefGoogle Scholar
  11. 11.
    Somkuwar SS, Fannon MJ, Staples MC, Zamora-Martinez ER, Navarro AI, Kim A, Quigley JA, Edwards S, Mandyam CD. Alcohol dependence-induced regulation of the proliferation and survival of adult brain progenitors is associated with altered BDNF-TrkB signaling. Brain Struct Funct. 2016;221(9):4319-4335.CrossRefGoogle Scholar
  12. 12.
    Topiwala A, Ebmeier KP. Effects of drinking on late-life brain and cognition. Evid. Based Mental Health. 2018;21(1):12-15.CrossRefGoogle Scholar
  13. 13.
    Vyunova TV, Andreeva L, Shevchenko K, Myasoedov N. Peptide-based anxiolytics: the molecular aspects of heptapeptide Selank biological activity. Protein Pept. Lett. 2018;25(10):914-923.CrossRefGoogle Scholar
  14. 14.
    Walker DW, Lee N, Heaton MB, King MA, Hunter BE. Chronic ethanol consumption reduces the neurotrophic activity in rat hippocampus. Neurosci. Lett. 1992;147(1):77-80.CrossRefGoogle Scholar
  15. 15.
    Yamada K, Nabeshima T. Brain-derived neurotrophic factor/TrkB signaling in memory processes. J. Pharmacol. Sci. 2003;91(4):267-270.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • L. G. Kolik
    • 1
    Email author
  • A. V. Nadorova
    • 1
  • T. A. Antipova
    • 1
  • S. V. Kruglov
    • 1
  • V. S. Kudrin
    • 1
  • A. D. Durnev
    • 1
  1. 1.V. V. Zakusov Research Institute of PharmacologyMoscowRussia

Personalised recommendations