Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats
The effects of a peptide anxiolytic Selank synthesized on the basis of the endogenous peptide tuftsin on memory impairment and content of brain-derived neurotrophic factor (BDNF) in brain structures were analyzed in outbred rats receiving 10% ethanol as the only source of fluid for 30 weeks. In the object recognition test, Selank (0.3 mg/kg a day, 7 days, intraperitoneally) produced a cognitive-stimulating effect in 9 months rats not exposed to ethanol (p<0.05) and prevented the formation of ethanol-induced memory and attention disturbances (p<0.01) developing during alcohol withdrawal. In ex vivo experiments, Selank prevented ethanol-induced increase in BDNF content in the hippocampus and frontal cortex (p<0.05). These results indicate positive effects of the tuftsin analogue on age-related memory disturbances associated with chronic alcohol intoxication and confirm the involvement of the neurotrophin mechanism related to BDNF production into the effect of Selank.
Key WordsSelank alcohol cognitive functions BDNF rats
Unable to display preview. Download preview PDF.
- 3.Teleshova ES, Bochkarev VK, Syunyakov TS, Bugaeva TP, Neznamov GG. Results of clinical and pharmacological studies of peptide anxiolitik Selank. Psikhiatriya. 2010;(4):26-35. Russian.Google Scholar
- 5.Hansen AW, Almeida FB, Bandiera S, Pulcinelli RR, Fragoso ALR, Schneider R Jr, Barros HMT, Gomez R. Taurine restores the exploratory behavior following alcohol withdrawal and decreases BDNF mRNA expression in the frontal cortex of chronic alcohol-treated rats. Pharmacol. Biochem. Behav. 2017;161(10):6-12.CrossRefGoogle Scholar
- 10.Schunck RV, Torres IL, Laste G, de Souza A, Macedo IC, Valle MT, Salomón JL, Moreira S, Kuo J, Arbo MD, Dallegrave E, Leal MB. Protracted alcohol abstinence induces analgesia in rats: possible relationships with BDNF and interleukin-10. Pharmacol. Biochem. Behav. 2015;135:64-69.CrossRefGoogle Scholar
- 11.Somkuwar SS, Fannon MJ, Staples MC, Zamora-Martinez ER, Navarro AI, Kim A, Quigley JA, Edwards S, Mandyam CD. Alcohol dependence-induced regulation of the proliferation and survival of adult brain progenitors is associated with altered BDNF-TrkB signaling. Brain Struct Funct. 2016;221(9):4319-4335.CrossRefGoogle Scholar