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Bulletin of Experimental Biology and Medicine

, Volume 167, Issue 5, pp 641–644 | Cite as

Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats

  • L. G. KolikEmail author
  • A. V. Nadorova
  • T. A. Antipova
  • S. V. Kruglov
  • V. S. Kudrin
  • A. D. Durnev
Article

The effects of a peptide anxiolytic Selank synthesized on the basis of the endogenous peptide tuftsin on memory impairment and content of brain-derived neurotrophic factor (BDNF) in brain structures were analyzed in outbred rats receiving 10% ethanol as the only source of fluid for 30 weeks. In the object recognition test, Selank (0.3 mg/kg a day, 7 days, intraperitoneally) produced a cognitive-stimulating effect in 9 months rats not exposed to ethanol (p<0.05) and prevented the formation of ethanol-induced memory and attention disturbances (p<0.01) developing during alcohol withdrawal. In ex vivo experiments, Selank prevented ethanol-induced increase in BDNF content in the hippocampus and frontal cortex (p<0.05). These results indicate positive effects of the tuftsin analogue on age-related memory disturbances associated with chronic alcohol intoxication and confirm the involvement of the neurotrophin mechanism related to BDNF production into the effect of Selank.

Key Words

Selank alcohol cognitive functions BDNF rats 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • L. G. Kolik
    • 1
    Email author
  • A. V. Nadorova
    • 1
  • T. A. Antipova
    • 1
  • S. V. Kruglov
    • 1
  • V. S. Kudrin
    • 1
  • A. D. Durnev
    • 1
  1. 1.V. V. Zakusov Research Institute of PharmacologyMoscowRussia

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