Effect of Stimulation of α2-Adrenergic Receptors on Action Potential of Working Cardiomyocytes in Rat Atrium

  • T. L. ZefirovEmail author
  • L. I. Faskhutdinov
  • N. I. Ziyatdinova
  • A. M. Galieva
  • A. L. Zefirov

The study examined the effect of clonidine hydrochloride (10—9-10—5 М) on electrical activity of working cardiomyocytes in rat right atrium. Stimulation of α2-adrenergic receptor with clonidine changed electrical activity of the heart. All tested concentrations of the agonist lengthened the action potential and decreased the firing rate of cardiomyocytes in a dose-dependent manner. The maximum effects of clonidine were observed at concentration of 10—5 М.

Key Words

α2-adrenergic receptor clonidine action potential atrium; rat 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • T. L. Zefirov
    • 1
    Email author
  • L. I. Faskhutdinov
    • 1
  • N. I. Ziyatdinova
    • 1
  • A. M. Galieva
    • 1
  • A. L. Zefirov
    • 2
  1. 1.Department of Anatomy, Physiology, and Human Health ProtectionKazan Federal UniversityKazanRussia
  2. 2.Department of Normal PhysiologyKazan State Medical UniversityKazanRussia

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