Role of Neurotrophic Factors BDNF and GDNF in Nervous System Adaptation to the Influence of Ischemic Factors

  • E. V. MitroshinaEmail author
  • T. A Mishchenko
  • T. V. Shishkina
  • M. V. Vedunova

We developed a complex in vitro model of ischemic damage. Analysis of hippocampal cell viability in primary cultures after modeling of various stress factors revealed the features of action of the main pathological factors of ischemia. Neurotrophic factors BDNF and GDNF produced pronounced neuroprotective effect during modeling both the complex ischemic damage and its individual pathophysiological components. Neurotrophic factor GDNF produced the most pronounced protective effect.

Key Words

ischemia brain-derived neurotrophic factor glial cell line-derived neurotrophic factor primary nerve cell cultures neuroprotection 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • E. V. Mitroshina
    • 1
    Email author
  • T. A Mishchenko
    • 1
  • T. V. Shishkina
    • 1
  • M. V. Vedunova
    • 1
  1. 1.N. I. Lobachevsky Nizhny Novgorod National Research State UniversityNizhny NovgorodRussia

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