Advertisement

Role of Transcription Factor Oct4 in Postnatal Development and Function of the Adrenal Cortex

  • N. V. YaglovaEmail author
  • S. S. Obernikhin
  • S. V. Nazimova
  • V. V. Yaglov
Article
  • 7 Downloads

We analyzed the expression of transcriptional factor Oct4 in rat adrenal cortical cells during postnatal development. It was found that Oct4 is expressed by typical cortical cells of the zona glomerulosa, zona fasciculata, and zona reticularis in pubertal and postpubertal periods. The maximum number of Oct4+ cells was found in the zona glomerulosa. An inverse correlation between the number of Oct4+ glomerulosa cells and serum level of aldosterone both in pubertal and postpubertal periods was revealed. After puberty, the number of Oct4+ glomerulosa cells directly correlated with the number of Ki-67+ cells. A hypothesis was put forward that Oct4 is involved in postnatal morphogenesis, regeneration, and functioning of the adrenal cortex.

Key Words

Oct4 pluripotency adrenal gland proliferation postnatal development 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bruder ED, Nagler AK, Raff H. Oxygen-dependence of ACTH-stimulated aldosterone and corticosterone synthesis in the rat adrenal cortex: developmental aspects. J. Endocrinol. 2002;172(3):595-604.CrossRefGoogle Scholar
  2. 2.
    Cheng L, Sung M.T, Cossu-Rocca P, Jones TD, MacLennan GT, De Jong J, Lopez-Beltran A, Montironi R, Looijenga LH. OCT4: biological functions and clinical applications as a marker of germ cell neoplasia. J. Pathol. 2007;211(1):1-9.CrossRefGoogle Scholar
  3. 3.
    Freedman BD, Kempna PB, Carlone DL, Shah M, Guagliardo NA, Barrett PQ, Gomez-Sanchez CE, Majzoub JA, Breault DT. Adrenocortical zonation results from lineage conversion of differentiated zona glomerulosa cells. Dev. Cell. 2013;26(6):666-673.CrossRefGoogle Scholar
  4. 4.
    Ishimoto H, Jaffe RB. Development and function of the human fetal adrenal cortex: a key component in the feto-placental unit. Endocr. Rev. 2011;32(3):317-355.CrossRefGoogle Scholar
  5. 5.
    Liedtke S, Stephan M, Kögler G. Oct4 expression revisited: potential pitfalls for data misinterpretation in stem cell research. Biol. Chem. 2008;389(7):845-850.CrossRefGoogle Scholar
  6. 6.
    Liu X, Huang J, Chen T, Wang Y, Xin S, Li J, Pei G, Kang J. Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells. Cell Res. 2008;18(12):1177-1189.CrossRefGoogle Scholar
  7. 7.
    Looijenga LH, Stoop H, de Leeuw HP, de Gouveia Brazao CA, Gillis AJ, van Roozendaal KE, van Zoelen EJ, Weber RF, Wolffenbuttel KP, van Dekken H, Honecker F, Bokemeyer C, Perlman EJ, Schneider DT, Kononen J, Sauter G, Oosterhuis JW. POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors. Cancer Res. 2003;63(9):2244-2250.Google Scholar
  8. 8.
    Lorente M, Mirapeix RM, Miguel M, Longmei W, Volk D, Cervós-Navarro J. Chronic hypoxia induced ultrastructural changes in the rat adrenal zona glomerulosa. Histol. Histopathol. 2002;17(1):185-190.Google Scholar
  9. 9.
    Mazroa S, Asker S. Ultrastructural changes in zona fasiculata cells of suprarenal cortex in adult male albino rats after short exposure to high ambient temperature and the effect of fish oil administration. Egypt. J. Histol. 2010;33(1):23-31.CrossRefGoogle Scholar
  10. 10.
    Mitani F. Functional zonation of the rat adrenal cortex: the development and maintenance. Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 2014;90(5):163-183.CrossRefGoogle Scholar
  11. 11.
    Mitani F, Mukai K, Miyamoto H, Suematsu M, Ishimura Y. The undifferentiated cell zone is a stem cell zone in adult rat adrenal cortex. Biochim. Biophys. Acta. 2003;1619(3):317-324.CrossRefGoogle Scholar
  12. 12.
    Niwa H, Miyazaki J, Smith AG. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 2000;24(4):372-376.CrossRefGoogle Scholar
  13. 13.
    Olariu V, Lövkvist C, Sneppen K. Nanog, Oct4 and Tet1 interplay in establishing pluripotency. Sci. Rep. 2016;6. ID 25438. doi:  https://doi.org/10.1038/srep25438
  14. 14.
    Pignatelli D, Xiao F, Gouveia AM, Ferreira JG, Vinson GP. Adrenarche in the rat. J. Endocrinol. 2006;191(1):301-308.CrossRefGoogle Scholar
  15. 15.
    Rizzino A, Wuebben EL. Sox2/Oct4: a delicately balanced partnership in pluripotent stem cells and embryogenesis. Biochim. Biophys. Acta. 2016;1859(6):780-791.CrossRefGoogle Scholar
  16. 16.
    Simandi Z, Horvath A, Wright LC, Cuaranta-Monroy I, De Luca I, Karolyi K, Sauer S, Deleuze JF, Gudas LJ, Cowley SM, Nagy L. OCT4 acts as an integrator of pluripotency and signal-induced differentiation. Mol. Cell. 2016;63(4):647-661.CrossRefGoogle Scholar
  17. 17.
    Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131(5):861-872.CrossRefGoogle Scholar
  18. 18.
    Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126(4):663-676.CrossRefGoogle Scholar
  19. 19.
    Vierbuchen T, Ostermeier A, Pang ZP, Kokubu Y, Südhof TC, Wernig M. Direct conversion of fibroblasts to functional neurons by defined factors. Nature. 2010;463:1035-1041.CrossRefGoogle Scholar
  20. 20.
    Yaglova NV, Tsomartova DA, Yaglov VV. Differences in production of adrenal steroid hormones in pubertal rats exposed to low doses of the endocrine disruptor DDT during prenatal and postnatal development. Biochemistry (Mosc). Suppl. Series B: Biomed. Chem. 2018;12(1):80-86.CrossRefGoogle Scholar
  21. 21.
    Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir GA, Ruotti V, Stewart R, Slukvin II, Thomson JA. Induced pluripotent stem cell lines derived from human somatic cells. Science. 2007;318:1917-1920.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • N. V. Yaglova
    • 1
    Email author
  • S. S. Obernikhin
    • 1
  • S. V. Nazimova
    • 1
  • V. V. Yaglov
    • 1
  1. 1.Laboratory of Endocrine System DevelopmentResearch Institute of Human PhysiologyMoscowRussia

Personalised recommendations