Advertisement

Model of Moderate Hyperhomocisteinemia Associated with Mechanical Injury: Dynamics of Morphometric Parameters of Microcirculatory Vessels

  • Yu. I. Pigolkin
  • D. B. Nikityuk
  • A. Yu. Asanov
  • D. P. BerezovskiiEmail author
  • S. S. Bachurin
  • S. S. Sas’ko
METHODS
  • 4 Downloads

A model of moderate hyperhomocysteinemia associated with mechanical injury of the musculoskeletal system was developed and experimentally substantiated. The adequacy of this model for studies of morphological and functional regularities is verified. This model can be used for the development of a new concept of evaluation of thrombotic complications of mechanical injury.

Key Words

thrombosis hyperhomocysteinemia vascular morphometry single nucleotide polymorphisms 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Berger UV, Larionova VI, Cherkashin DV. Structural polymorphisms C677T in gene 5,10-methylenetetrahydrofolate reductase and A2756G in gene for methionine synthase in men suffering from coronary heart disease. Vestn. Ross. Voen.-Med. Akad. 2014;(4):98-104. Russian.Google Scholar
  2. 2.
    Berezovskiĭ DP, Varavva TA, Faleeva TG, Pigolkin IuI, Kornienko IV. Forensic medical evaluation of hereditary predisposition to thrombophilia in the case of thrombotic complications of a mechanical injury. Sud.-Med. Ekspertiza. 2014;57(1):22-25. Russian.Google Scholar
  3. 3.
    Berezovskii DP, Kornienko IV, Pigolkin YuI. Forensic evaluation of thrombotic complications. Rostov on-Don, 2015. Russian.Google Scholar
  4. 4.
    Berezovsky DP, Majugin VY, Faleeva TG, Kurajan KM, Krainova NN, Habarova ОV, Voloshina GL, Varavva TA, Kornienko IV. Level of homocysteine at a trauma of the locomotor apparatus (experimental model on laboratory animals in conditions of methionine diets). Kuban. Nauch. Med. Vestn. 2011;(5):24-29. Russian.Google Scholar
  5. 5.
    Berezovskiĭ DP, Shatov DV, Kovalev BV, Dodokhova MA, Panenko ES, Kornienko IV. Investigations into post-traumatic complications in the practice of forensic medical expertiseof living people. Sud.-Med. Ekspertiza. 2012;55(6):9-12. Russian.Google Scholar
  6. 6.
    Barquet A, Gelink A, Giannoudis PV. Proximal femoral fractures and vascular injuries in adults: incidence, aetiology and outcomes. Injury. 2015;46(12):2297-2313.CrossRefGoogle Scholar
  7. 7.
    Bikdeli B, Jimenez D, Hawkins M, Ortíz S, Prandoni P, Brenner B, Decousus H, Masoudi FA, Trujillo-Santos J, Krumholz HM, Monreal M; RIETE Investigators. Rationale, Design and Methodology of the Computerized Registry of Patients with Venous Thromboembolism (RIETE). Thromb. Haemost. 2018;118(1):214-224.CrossRefGoogle Scholar
  8. 8.
    Cabo R, Hernes S, Slettan A, Haugen M, Ye S, Blomhoff R, Mansoor MA. Effect of genetic polymorphisms involved in folate metabolism on the concentration of serum folate and plasma total homocysteine (p-tHcy) in healthy subjects after short-term folic acid supplementation: a randomized, double blind, crossover study. Genes. Nutr. 2015;3(10). ID 456. doi:  https://doi.org/10.1007/s12263-015-0456-4.
  9. 9.
    Dayal S, Lentz SR. Murine models of hyperhomocysteinemia and their vascular phenotypes. Arterioscler. Thromb. Vasc. Biol. 2008;28(9):1596-1605.CrossRefGoogle Scholar
  10. 10.
    Giordano NJ, Jansson PS, Young MN, Hagan KA, Kabrhel C. Epidemiology, pathophysiology, stratification, and natural history of pulmonary embolism. Tech. Vasc. Interv. Radiol. 2017;20(3):135-140.CrossRefGoogle Scholar
  11. 11.
    Pfeiffer CM, Twite D, Shih J, Holets-McCormack SR, Gunter EW. Method Comparison for total plasma homocysteine between the Abbott IMx analyzer and an HPLC assay with internal standardization. Clin. Chem. 1999;45(1):152-153.Google Scholar
  12. 12.
    Randelli F, Capitani P, Pace F, Favilla S, Galante C, Randelli P. Bilateral femoral shaft fractures complicated by fat and pulmonary embolism: a case report. Injury. 2015;46(Suppl. 7):S28-S30.CrossRefGoogle Scholar
  13. 13.
    Spiroski I, Kedev S, Antov S, Arsov T, Krstevska M, Dzhekova-Stojkova S, Bosilkova G, Kostovska S, Trajkov D, Petlichkovski A, Strezova A, Efinska-Mladenovska O, Spiroski M. Methylenetetrahydrofolate reductase (MTHFR-677 and MTHFR-1298) genotypes and haplotypes and plasma homocysteine levels in patients with occlusive artery disease and deep venous thrombosis. Acta Biochim. Pol. 2008;55(3):587-594.Google Scholar
  14. 14.
    Wang KL, Chu PH, Lee CH, Pai PY, Lin PY, Shyu KG, Chang WT, Chiu KM, Huang CL, Lee CY, Lin YH, Wang CC, Yen HW, Yin WH, Yeh HI, Chiang CE, Lin SJ, Yeh SJ. Management of venous thromboembolisms: Part I. The consensus for deep vein thrombosis. Acta Cardiol. Sin. 2016;32(1):1-22.Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Yu. I. Pigolkin
    • 1
  • D. B. Nikityuk
    • 1
  • A. Yu. Asanov
    • 1
  • D. P. Berezovskii
    • 1
    Email author
  • S. S. Bachurin
    • 1
  • S. S. Sas’ko
    • 1
  1. 1.I. M. Sechenov First Moscow State Medical UniversityMinistry of Healthcare of the Russian Federation (Sechenov University)MoscowRussia

Personalised recommendations