Model of Moderate Hyperhomocisteinemia Associated with Mechanical Injury: Dynamics of Morphometric Parameters of Microcirculatory Vessels

  • Yu. I. Pigolkin
  • D. B. Nikityuk
  • A. Yu. Asanov
  • D. P. BerezovskiiEmail author
  • S. S. Bachurin
  • S. S. Sas’ko

A model of moderate hyperhomocysteinemia associated with mechanical injury of the musculoskeletal system was developed and experimentally substantiated. The adequacy of this model for studies of morphological and functional regularities is verified. This model can be used for the development of a new concept of evaluation of thrombotic complications of mechanical injury.

Key Words

thrombosis hyperhomocysteinemia vascular morphometry single nucleotide polymorphisms 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Yu. I. Pigolkin
    • 1
  • D. B. Nikityuk
    • 1
  • A. Yu. Asanov
    • 1
  • D. P. Berezovskii
    • 1
    Email author
  • S. S. Bachurin
    • 1
  • S. S. Sas’ko
    • 1
  1. 1.I. M. Sechenov First Moscow State Medical UniversityMinistry of Healthcare of the Russian Federation (Sechenov University)MoscowRussia

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