Advertisement

Structural Parameters of Mesenteric Lymph Nodes in Mice Exposed to Factors of Modeled Aerial Environment of Space Vehicles

  • K. A. VasyaninaEmail author
  • L. A. Klyueva
  • S. V. Klochkova
MORPHOLOGY AND PATHOMORPHOLOGY
  • 3 Downloads

The effects of inhalation exposure to a mixture containing acetone, acetaldehyde, and ethanol in concentrations typical of closed environment in space vehicles on the structure of mesenteric lymph nodes in F1 male mice were studied by histological technique. The long-term exposure to modeled atmosphere led to pronounced structural changes in these nodes that were clearly seen on day 22 and increased by day 36 of the experiment. The thickness of the capsule and trabeculae of mesenteric lymph nodes as well as diameter of lymphatic sinuses did not differ from the control values up to day 8, but then increased on days 22-70. Starting from day 22, the thickness of the medullary cords decreased and attained the minimum to the end of the experiments, which can indicate depletion of immunocytopoiesis and inhibition of humoral immunity. The present data are important for the space medicine, because they indicate structural changes in the peripheral lymphoid organs, the key elements of immune system.

Key Words

mesenteric lymph node space flight ethanol acetaldehyde acetone 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Kvaratskheliya AG, Klochkova SV, Alekseeva NT, Tutelian VA, Nikitiuk DB, Mukhamedieva LN. Morphologic changes in mesenteric lymph nodes of mice in the period of rehabilitation after completion of prolonged combined radiation and chemical exposure. Aviakosm. Ekol. Med. 2017;51(5):63-69. Russian.Google Scholar
  2. 2.
    Klochkova SV, Kvaratskheliya AG, Alekseeva NT, Nikityuk DB. Regeneration Potential of Lymphoid Tissue of Small Intestine in Mice after Exposure to Low-Intensity Radiation. Bull. Exp. Biol. Med. 2017;164(2):214-217.CrossRefPubMedGoogle Scholar
  3. 3.
    Lesniak AT, Rykova MP, Meshkov DO, Antropova EN, Mitirev GYu, Vorotnikova IE, Konstantinova IV. Cellular immunity of human and space mission. Aviakosm. Ekol. Med. 1998;32(1):29-35. Russian.Google Scholar
  4. 4.
    Mukhamedieva LN. The concept of hygienic evaluation of multicomponent chemical contamination of air on piloted orbital stations. Aviakosm. Ekol. Med. 2005;39(1):14-19. Russian.Google Scholar
  5. 5.
    Novikov DA, Novochadov VV. Statistical Methods in Biomedical Experiment (Typical Situations). Volgograd, 2005. Russian.Google Scholar
  6. 6.
    Oganesyan MV, Ponomarenko EA. Morphological changes of the trachea, bronchi and lungs of mice with long exposure of chemicals present in the airspace of manned spacecraft. Ross. Med.-Biol. Vestn. 2013;21(3):23-27. Russian.Google Scholar
  7. 7.
    Rykova MP. Immune system of Russian cosmonauts after orbital space flights. Human Physiol. 2013;39(5):557-566.CrossRefGoogle Scholar
  8. 8.
    Uyba VV, Ushakov IB, Sapetsky AO. The medical and biological risks associated with operations in deep space missions. Meditsina Ekstremal. Situatsii. 2017;59(1):43-64. Russian.Google Scholar
  9. 9.
    Chava SV, Buklis JV. Structural characteristics of immune formations of the mice spleen after low intensive radiated actions. Morfol. Vedomosti. 2011;(4):65-68. Russian.Google Scholar
  10. 10.
    Chetvertkov VS, Nikityuk DB, Shvetsov EV, Chava SV. The structural characteristic of the glandular apparatus of the mice duodenum after irradiation. Astrakhan. Med. Zh. 2012;7(4):266-270. Russian.Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • K. A. Vasyanina
    • 1
    Email author
  • L. A. Klyueva
    • 1
  • S. V. Klochkova
    • 1
  1. 1.I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)MoscowRussia

Personalised recommendations