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Formation of Alcohol Motivation in Monkeys (Macaca mulatta) Kept in Isolation

  • A. V. ShmaliyEmail author
  • L. E. Pavlova
  • Yu. P. Chuguev
  • L. G. Kolik
  • V. V. Kovalenko
  • S. B. Seredenin
  • B. A. Lapin
PRIMATOLOGY
  • 3 Downloads

The effects of environmental factors (flavors, different ethanol concentration, alcoholic deprivation, and food reinforcement) on the formation of alcohol motivation was studied in rhesus macaques (Macaca mulatta, n=6). Motivation for alcohol intake was induced in two stages: initiation (sessions 1-160) and formation of motivation (sessions 161-516). Monkeys preferred multifruit flavor and 4% ethanol solution, while ethanol deprivation did not stimulate alcohol consumption. The pronounced individual differences in the pattern of alcohol motivation were revealed: the intake of 4% ethanol solution ranged from 0.21±0.03 to 0.43±0.06 g/kg without food reinforcement and increased from 0.78±0.03 to 1.22±0.09 g/kg with food reinforcement. The results suggest that the proposed method is valid and can be used as an experimental model of alcohol dependence in non-human primates.

Key Words

rhesus macaques ethanol intake alcohol motivation 

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • A. V. Shmaliy
    • 1
    Email author
  • L. E. Pavlova
    • 1
  • Yu. P. Chuguev
    • 1
  • L. G. Kolik
    • 2
  • V. V. Kovalenko
    • 3
  • S. B. Seredenin
    • 2
  • B. A. Lapin
    • 1
  1. 1.Research Institute of Medical PrimatologySochiRussia
  2. 2.V.V. Zakusov Institute of PharmacologyMoscowRussia
  3. 3.Sochi State UniversitySochiRussia

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