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Development of a Bacteriophage Complex with Superhydrophilic and Superhydrophobic Nanotextured Surfaces of Metals Preventing Healthcare-Associated Infections (HAI)

  • V. V. Kaminskii
  • A. V. AleshkinEmail author
  • E. R. Zul’karneev
  • A. M. Zatevalov
  • I. A. Kiseleva
  • O. G. Efimova
  • K. A. Emelyanenko
  • A. M. Emelyanenko
  • L. B. Boinovich
Article

We studied antibacterial properties of organo-inorganic hybrid coatings on the AMg2 aluminum alloy including superhydrophilic and superhydrophobic nanotextured metal substrates with applied bacteriophage particles. Bactericidal activity of surfaces after artificial contamination with a bacterial suspension was evaluated. To increase bactericidal effect of the plates, bacteriophage was sorbed on their surface. In the experiments simulating possible spreading of HAI pathogens, higher bactericidal activity of superhydrophilic surfaces in comparison with superhydrophobic ones. Application of bacteriophage particles did not prevent primary colonization of textured metal surfaces by strains used in the experiment, but in some cases increases their bactericidal activity.

Key Words

bacteriophages nanoparticles aluminum healthcare-associated infections (HAI) bactericidal activity 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • V. V. Kaminskii
    • 1
  • A. V. Aleshkin
    • 1
    Email author
  • E. R. Zul’karneev
    • 1
  • A. M. Zatevalov
    • 1
  • I. A. Kiseleva
    • 1
  • O. G. Efimova
    • 1
  • K. A. Emelyanenko
    • 2
  • A. M. Emelyanenko
    • 2
  • L. B. Boinovich
    • 2
  1. 1.G. N. Gabrichevsky Moscow Research Institute of Epidemiology and MicrobiologyFederal Service for Surveillance on Consumer Rights Protection and Human WellbeingMoscowRussia
  2. 2.A. N. Frumkin Institute of Physical Chemistry and ElectrochemistryRussian Academy of ScienceMoscowRussia

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