Association of DNMT3B and DNMN3L Gene Polymorphisms with Early Pregnancy Loss
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A total of 100 women with early pregnancy loss were recruited and further classified into two subgroups: sporadic pregnancy loss and recurrent pregnancy loss; each subgroup consisted of 50 women. The control group included 56 women with normal pregnancies. Genotyping was performed by PCR with restriction fragment length polymorphism analysis. A statistically significant increase in the frequencies of TT genotype and T allele for DNMT3B rs2424913 polymorphism was found in the total patient group and in both patient subgroups in comparison with the control. Moreover, homozygous TT genotype was associated with increased risk of early pregnancy loss (both sporadic and recurrent). DNMT3B rs2424913 gene polymorphism in women can be used a marker of predisposition to early pregnancy loss and recurrent pregnancy loss.
Key WordsDNA methyltransferases early pregnancy loss single nucleotide polymorphisms
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- 1.Barišić A, Pereza N, Hodžić A, Ostojić S, Peterlin B. A Single nucleotide polymorphism of DNA methyltransferase 3B gene is a risk factor for recurrent spontaneous abortion. Am. J. Reprod. Immunol. 2017;78(6). doi: https://doi.org/10.1111/aji.12765.
- 3.Božović IB, Stanković A, Živković M, Vraneković J, Kapović M, Brajenović-Milić B. Altered LINE-1 methylation in mothers of children with Down syndrome. PLoS One. 2015;10(5). ID e0127423. doi: https://doi.org/10.1371/journal.pone.0127423.
- 6.European Society of Human Reproduction and Embryology. Guideline on the management of recurrent pregnancy loss. URL: https://www.eshre.eu/Guidelines-and-Legal/Guidelines/Recurrent-pregnancy-loss
- 7.Gao M, He D, Meng F, Li J, Shen Y. Associations of DNMT3B -149C>T and -2437T>A polymorphisms and lung cancer risk in Chinese population. World J. Surg. Oncol. 2016;14(1). ID 293.Google Scholar
- 13.Shen H, Wang L, Spitz MR, Hong WK, Mao L, Wei Q. A novel polymorphism in human cytosine DNA-methyltransferase-3B promoter is associated with an increased risk of lung cancer. Cancer Res. 2002;62(17):4992-4995.Google Scholar