Association of DNMT3B and DNMN3L Gene Polymorphisms with Early Pregnancy Loss

  • M. M. AzovaEmail author
  • A. A. Ahmed
  • A. Ait Aissa
  • M. L. Blagonravov

A total of 100 women with early pregnancy loss were recruited and further classified into two subgroups: sporadic pregnancy loss and recurrent pregnancy loss; each subgroup consisted of 50 women. The control group included 56 women with normal pregnancies. Genotyping was performed by PCR with restriction fragment length polymorphism analysis. A statistically significant increase in the frequencies of TT genotype and T allele for DNMT3B rs2424913 polymorphism was found in the total patient group and in both patient subgroups in comparison with the control. Moreover, homozygous TT genotype was associated with increased risk of early pregnancy loss (both sporadic and recurrent). DNMT3B rs2424913 gene polymorphism in women can be used a marker of predisposition to early pregnancy loss and recurrent pregnancy loss.

Key Words

DNA methyltransferases early pregnancy loss single nucleotide polymorphisms 


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • M. M. Azova
    • 1
    Email author
  • A. A. Ahmed
    • 1
  • A. Ait Aissa
    • 1
  • M. L. Blagonravov
    • 2
  1. 1.Department of Biology and General GeneticsMoscowRussia
  2. 2.V. A. Frolov Department of General Pathology and Pathophysiology, Medical InstitutePeoples’ Friendship University of Russia (RUDN University)MoscowRussia

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