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Effect of Ethosuximide on Audiogenic Epilepsy in Krushinsky—Molodkina Rats

  • I. B. Fedotova
  • O. V. Perepelkina
  • G. M. Nikolaev
  • N. M. Surina
  • I. I. PoletaevaEmail author
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The anticonvulsant effect of ethosuximide (T-type calcium channel blocker) was evaluated in Krushinsky–Molodkina rats predisposed to audiogenic epilepsy. Ethosuximide given with drinking water (300 mg/kg/day) over 45 days slightly reduced proneness to audiogenic epilepsy and increased locomotor activity of the animals at the periphery of the open field. Neonatal administration of ethosuximide (3-4 mg per animal, from 2 to 10 days of life) insignificantly modulated the parameters of audiogenic epilepsy in these animals at the age of 1.5 months and reduced manifestation of audiogenic myoclonic convulsion that developed after long daily sound presentation started at the age of 3 months. The findings attested to a weak anticonvulsant effect of ethosuximide on tonic convulsions with its predominant effect on convulsions with forebrain focus location.

Key Words

audiogenic epilepsy audiogenic myoclonus ethosuximide Krushinsky—Molodkina rats 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • I. B. Fedotova
    • 1
  • O. V. Perepelkina
    • 1
  • G. M. Nikolaev
    • 1
  • N. M. Surina
    • 1
  • I. I. Poletaeva
    • 1
    Email author
  1. 1.Faculty of BiologyM. V. Lomonosov Moscow State UniversityMoscowRussia

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