Influence of Age Factor on Respiratory Control of Isolated Cardiomyocytes and Mitochondria in Rats

  • L. P. TsapkoEmail author
  • S. A. Afanas’ev

We studied the peculiarities of oxidative and substrate phosphorylation in isolated cardiomyocytes and myocardial mitochondria in 2- and 15-month-old rats. It was shown that age factor reduces the degree of oxidation and phosphorylation coupling both in cardiomyocytes and in mitochondria, which was associated with the decrease in the rate of consumption of energy resources.

Key Words

phylogenesis cardiomyocytes mitochondria respiratory control substrate and oxidative phosphorylation 


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of SciencesTomskRussia

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