Advertisement

Effect of Electroconvulsive Therapy on Anxiety in Linear and Non-Linear Rats with Depressive-Like Disorders Induced by Ultrasound Stimulation

  • V. М. UshakovaEmail author
  • А. V. Gorlova
  • Е. А. Zubkov
  • А. Yu. Morozova
  • Ya. А. Zorkina
  • А. N. Inozemtsev
  • V. P. Chekhonin
Article
  • 7 Downloads

We performed a comparative study of the effect of electroconvulsive therapy on anxiety in outbred rats and Sprague-Dawley rats with depressive-like disorder induced by exposure to ultrasound of variable frequency (20-45 Hz). The anxiogenic effect of therapy was revealed in elevated plus maze and open-field tests in both linear and non-lineal rats, but was more pronounced in linear animals. Differences between outbred rats and Sprague-Dawley rats by the anxiety level were demonstrated. These results suggest that electroconvulsive therapy should be used with cautious in patients with depression and comorbid anxiety disorders. Pronounced behavioral differences between linear and non-linear rats should be considered when choosing optimal experimental object in this research field.

Key Words

electroconvulsive therapy depression ultrasound anxiety rats 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Morozova AY, Zubkov EA, Storozheva ZI, Kekelidze ZI, Chekhonin VP. Effect of ultrasonic irradiation on the development of symptoms of depression and anxiety in rats. Bull. Exp. Biol. Med. 2013;154(6):740-743.CrossRefGoogle Scholar
  2. 2.
    Akil H, Gordon J, Hen R, Javitch J, Mayberg H, McEwen B, Meaney MJ, Nestler EJ. Treatment resistant depression: a multi-scale, systems biology approach. Neurosci. Biobehav. Rev. 2018;84:272-288.CrossRefGoogle Scholar
  3. 3.
    Cardoso A, Carvalho LS, Lukoyanova EA, Lukoyanov NV. Effects of repeated electroconvulsive shock seizures and pilocarpine-induced status epilepticus on emotional behavior in the rat. Epilepsy Behav. 2009;14(2):293-299.CrossRefGoogle Scholar
  4. 4.
    Ionescu DF, Niciu MJ, Mathews DC, Richards EM, Zarate CA Jr. Neurobiology of anxious depression: a review. Depress. Anxiety. 2013;30(4):374-385.CrossRefGoogle Scholar
  5. 5.
    Medeiros da Frota Ribeiro C, Riva-Posse P. Use of ketamine in eldery patients with treatment-resistant depression. Curr. Psychiatry Rep. 2017;19(12). ID 107. doi:  https://doi.org/10.1007/s11920-017-0855-x.
  6. 6.
    Pellow S, Chopin P, File SE, Briley M. Validation of open closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J. Neurosci. Methods. 1985;14(3):149-167.CrossRefGoogle Scholar
  7. 7.
    Pirnia T, Joshi SH, Leaver AM, Vasavada M, Njau S, Woods RP, Espinoza R, Narr KL. Electroconvulsive therapy and structural neuroplasticity in neocortical, limbic and paralimbic cortex. Transl. Psychiatry. 2016;6(6). ID e832. doi:  https://doi.org/10.1038/tp.2016.102.CrossRefGoogle Scholar
  8. 8.
    van Buel EM, Bosker FJ, van Drunen J, Strijker J, Douwenga W, Klein HC, Eisel UL. Electroconvulsive seizures (ECS) do not prevent LPS-induced behavioral alterations and microglial activation. J. Neuroinflammation. 2015;12. ID 232. doi:  https://doi.org/10.1186/s12974-015-0454-x.
  9. 9.
    Wang Q, Timberlake MA 2nd, Prall K, Dwivedi Y. The recent progress in animal models of depression. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2017;77:99-109.CrossRefGoogle Scholar
  10. 10.
    Zincir S, Öztürk P, Bilgen AE, İzci F, Yükselir C. Levels of serum immunomodulators and alterations with electroconvulsive therapy in treatment-resistant major depression. Neuropsychiatr. Dis. Treat. 2016;12:1389-1396.CrossRefGoogle Scholar
  11. 11.
    Zolezzi M. Medication management during electroconvulsant therapy. Neuropsychiatr. Dis. Treat. 2016;12:931-939.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • V. М. Ushakova
    • 1
    • 2
    Email author
  • А. V. Gorlova
    • 2
  • Е. А. Zubkov
    • 1
  • А. Yu. Morozova
    • 1
  • Ya. А. Zorkina
    • 1
  • А. N. Inozemtsev
    • 2
  • V. P. Chekhonin
    • 1
    • 3
  1. 1.Department of Fundamental and Applied Neurobiology, V. P. Serbsky National Medical Research Center for Psychiatry and Narcology, Ministry of Health of the Russian FederationMoscowRussia
  2. 2.Department of Higher Nervous Activity, Faculty of BiologyM. V. Lomonosov Moscow State UniversityMoscowRussia
  3. 3.N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian FederationMoscowRussia

Personalised recommendations